Synthesis and micellar characterization of novel pH-sensitive thiol-ended triblock copolymer via combination of RAFT and ROP processes
Source abstract
Abstract
A new pH- sensitive thiol-ended amphiphilic triblock copolymer was synthesized by reversible addition fragmentation chain transfer polymerization. The critical micelle concentration (CMC) value for the synthesized PAA-b-PDMAEMAQ-b-PCL-SH triblock copolymer was determined to be 0.0079 g L-1 using fluorescence probe technique. The average sizes of PAA-b-PDMAEMAQ-b-PCL-SH micelles was obtained to be 30 ± 5 nm using TEM observation. It is expected that the synthesized PAA-b-PDMAEMAQ-b-PCL-SH triblock copolymer considered as a prospective candidate in nanomedicine applications such as chemo-photothermal therapy and drug delivery, mainly due to the strong affinity of thiol-ended group toward gold nanoparticle and its excellent micellization behavior.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Polymer Synthesis and Characterization · Antimicrobial agents and applications · biodegradable polymer synthesis and properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry (Organic chemistry), Miyaneh branch, Islamic Azad University, Miyaneh, Iran
Department of Chemistry, Payame Noor University, Tehran, Iran
Funding
"Iran National Science Foundation"(INSF) and tabriz Payame Noor University and Islamic Azad University
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