Synthesis, and characterization folate-conjugated photocleavable poly(4-substituted-ε-caprolactone) polymers for drug delivery
Source abstract
Abstract
Photo-cleavable polymers containing 5-hydroxy-2-nitrobenzyl alcohol (ONB) junction point between the target molecule of folic acid (FA) and the hydrophobic poly(4-substituted-ɛ-caprolactone) (PXCLn) chain were synthesized. FA –terminated ONB-PXCLn polymers formed micelles with critical micelle concentration (CMC) 1.2 – 64.3 mg L−1. Fluorescence emission spectroscopy indicated the release of Nile red encapsulated FA-ONB-PXCLn micelles in response to irradiation. Light-triggered bursts released were observed for drug-loaded FA-ONB-PXCLn micelles. The nanoparticles exhibited nonsignificant toxicity at concentrations up to 300 µg mL−1. Flow cytometry revealed that the uptake of folate-targeted doxorubicin (DOX) -encapsulated micelles by HeLa cells was faster than that of free DOX.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Polymer Synthesis and Characterization · Photochromic and Fluorescence Chemistry · Conducting polymers and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Graduate Institute of Natural Products, Chang Gung University, Tao-Yuan, Taiwan;
Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan;
Division of Natural Science, Center of General Education, Chang Gung University, Tao-Yuan, Taiwan
Funding
Ministry of Science and Technology · Chang Gung Memorial Hospital
References (36)
Show source-provided references
1. 10.1021/ma402301w10.1021/ma402301w ↗
2. 10.1016/j.carbpol.2013.12.06210.1016/j.carbpol.2013.12.062 ↗
3. 10.1002/marc.20100010810.1002/marc.201000108 ↗
4. 10.1039/C5CC05792B10.1039/C5CC05792B ↗
5. 10.1016/j.jconrel.2007.03.02310.1016/j.jconrel.2007.03.023 ↗
6. 10.1021/ma201924h10.1021/ma201924h ↗
7. 10.1039/C5CC06143A10.1039/C5CC06143A ↗
8. 10.1039/C5CC04087F10.1039/C5CC04087F ↗
9. 10.1039/c3cs35469e10.1039/c3cs35469e ↗
10. 10.1016/j.carbpol.2012.12.05110.1016/j.carbpol.2012.12.051 ↗
11. 10.1021/bm300304t10.1021/bm300304t ↗
12. 10.1039/c3ra42763c10.1039/c3ra42763c ↗
13. 10.1039/B9PY00218A10.1039/B9PY00218A ↗
14. 10.1021/ma400659h10.1021/ma400659h ↗
15. 10.1016/j.jconrel.2017.02.02310.1016/j.jconrel.2017.02.023 ↗
16. 10.1039/C2TB00328G10.1039/C2TB00328G ↗
17. 10.1039/c1jm11270h10.1039/c1jm11270h ↗
18. 10.1016/j.jconrel.2016.04.01510.1016/j.jconrel.2016.04.015 ↗
19. 10.1016/S0169-409X(99)00062-910.1016/S0169-409X(99)00062-9 ↗
20. 10.1039/C4PY01607F10.1039/C4PY01607F ↗
21. 10.1039/C5PY00023H10.1039/C5PY00023H ↗
22. 10.1016/j.reactfunctpolym.2014.05.00310.1016/j.reactfunctpolym.2014.05.003 ↗
23. 10.1021/bm500126310.1021/bm5001263 ↗
24. 10.1039/C5TB00900F10.1039/C5TB00900F ↗
25. 10.1039/C5TB01063B10.1039/C5TB01063B ↗
26. 10.1021/ma902680610.1021/ma9026806 ↗
27. 10.1021/ma990054x10.1021/ma990054x ↗
28. 10.1021/bm200604h10.1021/bm200604h ↗
29. 10.1021/bm101058w10.1021/bm101058w ↗
30. 10.1016/j.biomaterials.2009.07.02010.1016/j.biomaterials.2009.07.020 ↗
31. 10.1016/j.biomaterials.2011.11.03510.1016/j.biomaterials.2011.11.035 ↗
32. 10.1021/la301534h10.1021/la301534h ↗
33. 10.1007/s11095-010-0233-410.1007/s11095-010-0233-4 ↗
34. 10.1016/j.jconrel.2011.07.04110.1016/j.jconrel.2011.07.041 ↗
35. 10.1021/bm200375x10.1021/bm200375x ↗
36. 10.1007/s00018-009-0053-z10.1007/s00018-009-0053-z ↗