Poly (amido amine) G5 modified mesoporous silica-based pH-responsive drug-delivery system for tetracycline and ibuprofen
Source abstract
Abstract
In this novel communication, mesoporous silica/poly (amidoamine) generation 5 nanocomposite was synthesized through 3-glycidoxypropyltrimethoxysilane (GPTMS) and its functionality was studied. Successful functionalization of mesoporous silica with PAMAM was studied through Transmission electron microscopy (TEM). N2 adsorption-desorption was indicative of a surface area of 1,321 m2/g and a mean pore diameter of 2 nm. Successful drug loading and optimal release were confirmed using Fourier transform infrared (FTIR) and ultraviolet-visible spectroscopy (UV-Vis), respectively. Furthermore, at 256 μg/mL concentration samples demonstrated antibacterial activity toward Staphylococcus aureus and Escherichia coli bacteria, and cell viability for all samples after 72 h was more than 70%.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Drug Delivery Systems · Nanoparticle-Based Drug Delivery · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Materials Science and Engineering, Tarbiat Modares University, Tehran, Iran
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