DataVXInternational Journal of Polymeric Materials and Polymeric BiomaterialsPaper
journal article·2020-02-11

Integration of PLGA Microparticles in Collagen-Based Matrices: Tunable Scaffold Properties and Interaction Between Microparticles and Human Epithelial-Like Cells

L.C. Gallo, M. Madaghiele, L. Salvatore, A. Barca, S. Scialla, S. Bettini, L. Valli, T. Verri, V. Bucalá, A. Sannino

International Journal of Polymeric Materials and Polymeric Biomaterials· Volume 69· Issue 3
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Source abstract

Abstract

The feasibility to obtain highly porous collagen-based scaffolds (SCs) integrated with uniformly dispersed poly(lactide-co-glycolide) (PLGA) microparticles (MPs) was evaluated. PLGA-MPs were prepared by double emulsion technique and SCs with different amounts of MPs (SC/PLGA-MPs) were produced. Results showed that SC/PLGA-MPs could be successfully manufactured, the PLGA-MPs being physically retained in the SCs, without affecting the porous structure. PLGA-MPs also increased the SC hydrophilicity, acted as a mechanical reinforcement and retarded the degradation rate. In addition, the interactions between MPs and Caco-2 cells did not interfere with the correct morphological, adhesion and proliferation pathways.
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Research context

Composites

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Bone Tissue Engineering Materials · Tissue Engineering and Regenerative Medicine

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biology, Biochemistry and Pharmacy, Universidad Nacional del Sur, Bahía Blanca, Argentina;

Pilot Plant of Chemical Engineering, PLAPIQUI (UNS-CONICET), Bahía Blanca, Argentina;

Department of Engineering for Innovation, University of Salento, Lecce, Italy;

Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy;

Department of Chemical Engineering, Universidad Nacional del Sur, Bahía Blanca, Argentina

Funding

Italian Ministry of Education, University and Research (MIUR) · Universidad Nacional del Sur (Argentina) · Eurica-Erasmus Mundus Program · University of Salento (Italy)

References (40)

Show source-provided references
1. 10.1155/2011/29060210.1155/2011/290602 ↗
2. 10.1016/j.biotechadv.2017.01.00110.1016/j.biotechadv.2017.01.001 ↗
3. 10.1080/23808993.2016.114000410.1080/23808993.2016.1140004 ↗
4. 10.1100/2012/69513710.1100/2012/695137 ↗
5. 10.1007/978-1-4939-1865-210.1007/978-1-4939-1865-2 ↗
6. 10.1002/term.186510.1002/term.1865 ↗
7. 10.3389/fphys.2014.0035410.3389/fphys.2014.00354 ↗
8. 10.7150/ijms.1076110.7150/ijms.10761 ↗
9. 10.1515/esp-2017-000510.1515/esp-2017-0005 ↗
10. 10.1089/ten.teb.2013.012610.1089/ten.teb.2013.0126 ↗
11. Inchingolo F. · Eur. Rev. Med. Pharmacol. Sci · 2012 · 16 · 1222
12. 10.3109/21691401.2016.114673110.3109/21691401.2016.1146731 ↗
13. 10.1002/bip.2087110.1002/bip.20871 ↗
14. 10.1080/00914037.2016.121753310.1080/00914037.2016.1217533 ↗
15. 10.1002/term.239210.1002/term.2392 ↗
16. 10.1016/j.jconrel.2014.11.02110.1016/j.jconrel.2014.11.021 ↗
17. 10.1016/j.jconrel.2006.04.01110.1016/j.jconrel.2006.04.011 ↗
18. 10.1016/j.actbio.2008.07.03010.1016/j.actbio.2008.07.030 ↗
19. 10.1021/acs.biomac.5b0082910.1021/acs.biomac.5b00829 ↗
20. 10.1002/chem.20160321010.1002/chem.201603210 ↗
21. 10.1016/j.jcis.2017.04.06710.1016/j.jcis.2017.04.067 ↗
22. 10.1016/S0169-409X(02)00228-410.1016/S0169-409X(02)00228-4 ↗
23. 10.1016/j.ejpb.2007.08.00110.1016/j.ejpb.2007.08.001 ↗
24. 10.1016/j.ejps.2008.11.01510.1016/j.ejps.2008.11.015 ↗
25. 10.1016/j.colsurfb.2012.09.03510.1016/j.colsurfb.2012.09.035 ↗
26. 10.1016/j.proghi.2011.11.00110.1016/j.proghi.2011.11.001 ↗
27. 10.1016/j.ejpb.2016.07.00310.1016/j.ejpb.2016.07.003 ↗
28. 10.1016/j.powtec.2014.08.02110.1016/j.powtec.2014.08.021 ↗
29. 10.1016/j.biomaterials.2004.02.05210.1016/j.biomaterials.2004.02.052 ↗
30. 10.1016/0142-9612(96)81413-X10.1016/0142-9612(96)81413-X ↗
31. 10.1002/jbm.a.3151710.1002/jbm.a.31517 ↗
32. 10.1016/j.msec.2016.10.03010.1016/j.msec.2016.10.030 ↗
33. 10.1038/nprot.2008.7310.1038/nprot.2008.73 ↗
34. Salvatore L. · J. Biomed. Mater. Res. A · 2014 · 102 · 4406
35. 10.1016/j.jart.2016.01.00110.1016/j.jart.2016.01.001 ↗
36. 10.1590/0104-1428.232310.1590/0104-1428.2323 ↗
37. 10.1155/2012/12395310.1155/2012/123953 ↗
38. 10.1063/1.486426310.1063/1.4864263 ↗
39. 10.1016/j.polymer.2009.05.03510.1016/j.polymer.2009.05.035 ↗
40. 10.3390/molecules2210170710.3390/molecules22101707 ↗