Development of Ga-68 radiolabeled DOTA functionalized and acetylated PAMAM dendrimer-coated iron oxide nanoparticles as PET/MR dual-modal imaging agent
Source abstract
Abstract
Gallium-68 radiolabeled DOTA- acetyl-PAMAM coated iron oxide nanoparticles (NPs) were developed as dual-modality agents for PET-MR imaging. The increase in the chelator content, acetylation step, and radiolabeling condition had distinctive effects on the physical, biological, and radiochemical properties of NPs. The r2 relaxivity coefficient value of the NPs was 96.7 mM−1s−1. High accumulation of candidate NPs was in the liver and spleen and about 3.4% ID/g uptake (tissue sampling), and a distinctive uptake (PET-CT image) were observed in the tumor site. These NPs could be used as the dual-modality agent for the diagnosis of the tumors via PET-MR imaging.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Dendrimers and Hyperbranched Polymers · Nanoparticle-Based Drug Delivery · Lanthanide and Transition Metal Complexes
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Radiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran
Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
Department of Chemical Engineering, University of Science and Technology of Mazandaran, Behshahr, Iran
Department of Medical Physics, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
Funding
Iran National Science Foundation · Tehran University of Medical Sciences and Health Services
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