A high-toughness and high cell adhesion polyvinyl alcohol（PVA-hyaluronic acid (HA)-human-like collagen (HLC) composite hydrogel for cartilage repair
Source abstract
Abstract
Polyvinyl alcohol (PVA) has good mechanical stability and flexibility. However, PVA hydrogels of low compressive strength and low cell adhesion is still considered difficult to apply to tissue engineering cartilage. In this paper, we prepared PVA-HA-HLC hydrogel by freeze-thaw method. The results showed that the hydrogel had an average pore diameter of 100–300 μm, a porosity of 94.52%, a maximum compressive strain of 90%, and a compressive strength of 5.56 MPa. Animal cartilage defect test results showed that PVA-HA-HLC hydrogel repaired cartilage defects. In short, PVA-HA-HLC hydrogels could be used as cartilage repair scaffold.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Osteoarthritis Treatment and Mechanisms · Knee injuries and reconstruction techniques · Silk-based biomaterials and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi’an, China;
Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi’an, China;
Biotech. & Biomed. Research Institute, Northwest University, Xi’an, China
Funding
National Natural Science Foundation of China · Shaanxi Key Laboratory of Degradable Biomedical Materials Program
References (35)
Show source-provided references
1. 10.1186/ar7410.1186/ar74 ↗
2. 10.1073/pnas.170385611410.1073/pnas.1703856114 ↗
3. 10.1177/036354650730739610.1177/0363546507307396 ↗
4. 10.1002/art.2402110.1002/art.24021 ↗
5. 10.1093/oxfordjournals.aje.a00948210.1093/oxfordjournals.aje.a009482 ↗
6. 10.1002/jbm.a.3300510.1002/jbm.a.33005 ↗
7. 10.1089/ten.TEA.2010.032210.1089/ten.TEA.2010.0322 ↗
8. 10.1016/j.carbpol.2013.06.02010.1016/j.carbpol.2013.06.020 ↗
9. 10.1016/S0142-9612(00)00242-810.1016/S0142-9612(00)00242-8 ↗
10. 10.1021/ma990758710.1021/ma9907587 ↗
11. 10.1002/jbm.a.3125510.1002/jbm.a.31255 ↗
12. 10.1302/0301-620X.79B6.760610.1302/0301-620X.79B6.7606 ↗
13. 10.1016/j.colsurfb.2015.05.00810.1016/j.colsurfb.2015.05.008 ↗
14. 10.1002/mabi.20080022310.1002/mabi.200800223 ↗
15. 10.1002/jbm.1004210.1002/jbm.10042 ↗
16. 10.1016/j.carbpol.2012.10.02810.1016/j.carbpol.2012.10.028 ↗
17. 10.1126/science.122245410.1126/science.1222454 ↗
18. 10.1038/nmat189010.1038/nmat1890 ↗
19. 10.1016/j.biomaterials.2017.01.02910.1016/j.biomaterials.2017.01.029 ↗
20. 10.1016/j.actbio.2016.02.01610.1016/j.actbio.2016.02.016 ↗
21. 10.1002/bit.2082810.1002/bit.20828 ↗
22. 10.1002/bab.103210.1002/bab.1032 ↗
23. 10.1088/1748-6041/3/4/04411110.1088/1748-6041/3/4/044111 ↗
24. 10.1002/jbm.a.3144010.1002/jbm.a.31440 ↗
25. 10.1016/j.msec.2014.11.03410.1016/j.msec.2014.11.034 ↗
26. 10.1039/C3TB21842B10.1039/C3TB21842B ↗
27. 10.1016/j.biotechadv.2017.01.00110.1016/j.biotechadv.2017.01.001 ↗
28. 10.1021/ma049932410.1021/ma0499324 ↗
29. 10.1016/j.ijbiomac.2018.08.05610.1016/j.ijbiomac.2018.08.056 ↗
30. 10.1016/j.bioactmat.2016.11.00110.1016/j.bioactmat.2016.11.001 ↗
31. 10.1016/j.biomaterials.2013.11.00910.1016/j.biomaterials.2013.11.009 ↗
32. 10.1016/j.msec.2017.05.14110.1016/j.msec.2017.05.141 ↗
33. 10.1016/j.euromechsol.2018.12.00110.1016/j.euromechsol.2018.12.001 ↗
34. 10.1016/S0142-9612(00)00102-210.1016/S0142-9612(00)00102-2 ↗
35. 10.1016/j.biomaterials.2016.01.01910.1016/j.biomaterials.2016.01.019 ↗