DataVXInternational Journal of Polymeric Materials and Polymeric BiomaterialsPaper
journal article·2018-10-13

Prolonged drug release using PCL–TMZ nanofibers induce the apoptotic behavior of U87 glioma cells

Rezvan Tavakoli, Saeid Vakilian, Fatemeh Jamshidi-Adegani, Samaneh Sharif, Abdolreza Ardeshirylajimi, Masoud Soleimani

International Journal of Polymeric Materials and Polymeric Biomaterials· Volume 67· Issue 15
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Source abstract

Abstract

In situ prolonged delivery of drugs at the site of tumor can be satisfactorily accelerated patient recovery. We compared the effect of temozolomide while incorporated by polycaprolactone nanofibers on the apoptotic behavior of U87 glioma cells. After biocompatibility evaluation of nanofibers by scanning electron microscope and 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide analysis, the apoptosis of U87 cells was evaluated using p53, Bcl2 and Bax genes expression. It was found that nanofiber-temozolomide group showed a greater ability to induce apoptosis as well as have a significantly diminished initial burst release of drug compared with other groups and have promising potential in treating cancer.
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Research context

NanomaterialsBiomaterials

OpenAlex topics: RNA Interference and Gene Delivery · Cell death mechanisms and regulation · Autophagy in Disease and Therapy

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Stem Cell Technology Research Center, Tehran, Iran

Laboratory for Stem Cell & Regenerative Medicine, Chair of Oman’s Medicinal Plants & Marine Natural Products, University of Nizwa, Nizwa, Oman

Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Department of Hematology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran

Funding

the Stem Cell Technology Research Center

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