The hydrogels based on peptide/collagen as potential multifunctional materials for soft tissue filling and inhibition of tumor growth
Source abstract
Abstract
In this study, injectable peptide hydrogels were designed and fabricated based on the crosslinking of peptides and hyaluronic acid (HA) by 1,4-butanediol diglycidyl ether (BDDE). An anticancer bioactive peptide (ACBP), plant peptide (PB), fishbone collagen (FBC), and bovine bone collagen (BBC) were incorporated as peptide sources to assess their characteristics. The peptide hydrogels form a new amide bond (–CONH) between the peptide and HA. The construct functional peptide hydrogels with anti-inflammatory and anti-biodegradation properties, while the ACBP-fabricated hydrogel may inhibit tumor growth in a tumor transplantation model in vivo for cancer therapy and skin tissue engineering.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Collagen: Extraction and Characterization · Hydrogels: synthesis, properties, applications · Silk-based biomaterials and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Clinical Medical Research Center, Affiliated Hospital, Inner Mongolia Medical University, Huhhot, China
Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi’an, China
Key Laboratory of Medical Cell Biology in Inner Mongolia Autonomous Region, Huhhot, China
Department of Gastrointestinal Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China
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