Enhanced biological activity of polyphenols on conjugation with gellan gum
Source abstract
Abstract
The gellan gum was coupled with hydrophobic polyphenols, curcumin and naringenin using dicyclohexylcarbodiimide and dimethylaminopyridine reaction. The formation of conjugates was ascertained by spectral, thermal, X-ray diffraction, and scanning electron microscopic studies. In silico simulations validated the successful interaction between polysaccharide and polyphenols. The conjugates self-assemble in aqueous solution was confirmed by fluorescence spectroscopy and dynamic light scattering. Further, evaluation unveiled significantly improved radical scavenging and antibacterial activity of conjugates over pristine polyphenols. The conjugates revealed higher anti-cancer activity against human ovarian carcinoma cell lines. In conclusion, polyphenol conjugates showed improved therapeutic efficiency and delivery on conjugation with gum.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Polysaccharides Composition and Applications · Polysaccharides and Plant Cell Walls · Curcumin's Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, India
Faculty of Health Sciences, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, University of the Witwatersrand, Parktown, South Africa
References (40)
Show source-provided references
1. 10.1016/j.addr.2008.09.00110.1016/j.addr.2008.09.001 ↗
2. 10.1016/S0378-5173(01)00720-710.1016/S0378-5173(01)00720-7 ↗
3. 10.1016/j.carbpol.2012.11.02110.1016/j.carbpol.2012.11.021 ↗
4. 10.1016/j.carbpol.2013.08.06710.1016/j.carbpol.2013.08.067 ↗
5. 10.1016/j.ijbiomac.2016.01.03710.1016/j.ijbiomac.2016.01.037 ↗
6. 10.1016/j.carbpol.2015.07.06810.1016/j.carbpol.2015.07.068 ↗
7. 10.1021/acs.jafc.7b0225010.1021/acs.jafc.7b02250 ↗
8. 10.1007/s00289-018-2538-010.1007/s00289-018-2538-0 ↗
9. 10.1016/j.jcis.2011.03.07110.1016/j.jcis.2011.03.071 ↗
10. 10.1016/j.progpolymsci.2007.05.00810.1016/j.progpolymsci.2007.05.008 ↗
11. 10.1016/0008-6215(83)88361-X10.1016/0008-6215(83)88361-X ↗
12. 10.1016/j.ijbiomac.2017.11.09910.1016/j.ijbiomac.2017.11.099 ↗
13. 10.1016/j.foodhyd.2005.10.01410.1016/j.foodhyd.2005.10.014 ↗
14. Phillips G. O. · 2000
15. Williams P. A. · 2002 · 11
16. Norton I. · Spec. Publ. R Soc. Chem. · 2002 · 278 · 187
17. 10.1016/j.biomaterials.2015.07.02210.1016/j.biomaterials.2015.07.022 ↗
18. 10.4161/oxim.2.5.949810.4161/oxim.2.5.9498 ↗
19. 10.1093/ajcn/79.5.72710.1093/ajcn/79.5.727 ↗
20. 10.1021/bc034186d10.1021/bc034186d ↗
21. 10.1007/s10973-013-3463-y10.1007/s10973-013-3463-y ↗
22. 10.1007/s13346-018-0543-310.1007/s13346-018-0543-3 ↗
23. 10.3109/03639045.2014.90246610.3109/03639045.2014.902466 ↗
24. 10.1186/1477-3155-5-310.1186/1477-3155-5-3 ↗
25. Ji P. · Drug Des. Dev. Ther. · 2016 · 10 · 911
26. 10.1002/cncr.2130010.1002/cncr.21300 ↗
27. 10.1371/journal.pone.013102610.1371/journal.pone.0131026 ↗
28. 10.1016/j.colsurfb.2015.06.02010.1016/j.colsurfb.2015.06.020 ↗
29. Chauhan S. K. · Indian J. Pharm. Sci. · 1999 · 61 · 58
30. 10.1208/s12249-016-0537-810.1208/s12249-016-0537-8 ↗
31. 10.1016/j.carbpol.2007.01.01610.1016/j.carbpol.2007.01.016 ↗
32. 10.1016/j.carbpol.2013.01.02510.1016/j.carbpol.2013.01.025 ↗
33. 10.1002/btm2.1010510.1002/btm2.10105 ↗
34. 10.1166/jbn.2013.155810.1166/jbn.2013.1558 ↗
35. 10.1016/j.jpba.2005.07.04210.1016/j.jpba.2005.07.042 ↗
36. 10.1111/j.1365-2672.2011.05070.x10.1111/j.1365-2672.2011.05070.x ↗
37. 10.1007/s13205-019-1835-010.1007/s13205-019-1835-0 ↗
38. 10.1016/j.ijbiomac.2014.06.04310.1016/j.ijbiomac.2014.06.043 ↗
39. 10.1016/j.carbpol.2011.01.01710.1016/j.carbpol.2011.01.017 ↗
40. 10.1007/3-540-48349-710.1007/3-540-48349-7 ↗