Protein expression by bone mesenchymal stem cells cultivated in PLLA scaffolds with different pore geometry
Source abstract
Abstract
The effects of poly(L,L-lactide) (PLLA) scaffold with axial and isotropic structure were investigated on functional activity of rabbit bone mesenchymal stem cells (BMSCs). PLLA scaffolds were processed by freeze-dry technique at different temperatures of the scaffold frost – −196 °C, −25 °C and 0 °C. Scaffolds with different pore sizes were obtained by adding 5 or 10% of water phase. Scaffolds were modified by collagen type I solution. The pore sizes of polymer scaffolds were ranging from 5 to 150 µm. More protein secretion was observed in the surface-modified scaffolds than in the unmodified after 2 weeks of cultivation in vitro.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · biodegradable polymer synthesis and properties · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Cytology of the Russian Academy of Sciences (RAS), St. Petersburg, Russia;
Ioffe Physico-Technical Institute of the Russian Academy of Sciences, St. Petersburg, Russia;
Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia
Funding
Russian Science Foundation
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