Living Devices for Organ Replacement: The Rise of Bioartificial Organ Engineering
Source abstract
Abstract
Organ failure remains one of the foremost medical and socioeconomic challenges of the twenty-first century, with global transplant waiting lists far exceeding the supply of donor organs. Chronic supportive therapies sustain life but do not restore organ function, underscoring an urgent need for curative alternatives. Bioartificial organs represent a major frontier in organ replacement, driven by converging advances in cell biology, biomaterials science, and bioengineering. By integrating living cells or biologically derived matrices with engineered devices or scaffolds, these systems aim to restore functions that purely mechanical supports cannot reproduce. This review examines the principal technological platforms underpinning the field, including cell encapsulation, decellularization and recellularization, three-dimensional bioprinting, organoids, organ-on-chip systems, and xenotransplantation, and discusses their application to kidney, liver, heart, pancreas, and lung replacement. Across organ systems, progress is advancing from experimental proof-of-concept toward modular and increasingly translational platforms, although whole-organ bioengineering remains largely preclinical for the most structurally complex targets. The major unresolved barriers include vascularization, immune compatibility, scalable cell manufacturing, durable function, and stable integration between biological and engineered components. Overall, bioartificial organ engineering is evolving toward clinically relevant therapeutic strategies capable of complementing, bridging, or eventually reducing dependence on donor-organ transplantation.
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Research context
OpenAlex topics: Tissue Engineering and Regenerative Medicine · 3D Printing in Biomedical Research · Liver physiology and pathology
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, Italy
Department of Engineering and Architecture, University of Enna “Kore”, 94100 Enna, Italy
Department of Medical, Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, University of Catania, 95123 Catania, Italy
Mediterranean Foundation “GB Morgagni”, 95125 Catania, Italy
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