Manganese Could Indirectly Promote Generation and Propagation of the Yeast Prion [URE3] and Increase Molecular Chaperones Expression in Budding Yeast
Source abstract
Abstract
Prion diseases are caused by self-propagating and transmissible alternative conformations of certain proteins, which induce neurotoxicity and lead to transmissible spongiform encephalopathy (TSE) in mammalian. Prions were also found in fungi, and in particular, the yeast Saccharomyces cerevisiae. Manganese (Mn) is an essential nutrient and plays crucial roles in central nervous system. However, high concentration of manganese is regarded as an environmental neuronal stressor which would induce striatal neurotoxicity. Long-term exposure to high concentration of manganese would increase the proportion of the infectiously pathogenic isoform (PrPSc) of prion protein. Additionally, increase of manganese levels was found to be age-related in human brain. Here, we studied the effect of manganese on prion using budding yeast prion [URE3] as model organism. We found the exposure to manganese can enhance the de novo generation and propagation of yeast prion [URE3], as well as the expression levels of chaperones Hsp104p and Hsp70p, in a dose-dependent manner.
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Research context
OpenAlex topics: Prion Diseases and Protein Misfolding · Heavy Metal Exposure and Toxicity · Trace Elements in Health
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Food Science and Engineering, Hainan Tropical Ocean University, 1 Yucai Road, Sanya 572022, China
Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Road, Xiamen 361021, China
University of the Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China
Jiangmen Municipal Bureau of Ecology and Environment, 140 North Shengli Road, Pengjiang District, Jiangmen 529000, China
Funding
Hainan Provincial Natural Science Foundation · National Natural Science Foundation of China · Innovation platform for Academinicians of Hainan Province · Hainan Province Graduate Student Innovation Research Project · Graduate Innovation Project of Hainan Tropical Ocean University
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