journal article·2026-04-24Open access

Contextual Zero-Knowledge Authentication with IPFS-Backed Hyperledger Fabric for Privacy-Preserving Blood Supply Chain Management

Leda Kamal, Jeberson Retna Raj R

Applied Sciences· Volume 16· Issue 9

Abstract

Ensuring data security and privacy has emerged as a serious concern in the realm of blood supply chain. This is mainly because of sensitivity of donor information, the involvement of multiple stakeholders, and the need for transparent traceability. This paper proposes a novel privacy-preserving, permissioned blockchain framework for blood supply chain management that integrates Hyperledger Fabric, the InterPlanetary File System (IPFS), and a Zero-Knowledge Proof (ZKP)-based authentication protocol. The framework introduces a Pseudonymous Role-Bound Zero-Knowledge Authentication (PRZKA) mechanism that enables donors to authenticate and authorize access to their medical data without revealing their real identities. Context-specific pseudonyms derived through cryptographic hash-to-curve operations ensure unlinkability across different healthcare interactions, while Schnorr-style challenge–response proofs prevent replay attacks and credential misuse. Sensitive donor information is protected using Fabric Private Data Collections, whereas encrypted medical records are stored off-chain in IPFS, with only secure content identifiers recorded on the blockchain. Smart contracts enforce fine-grained, consent-aware access control policies and maintain immutable audit logs of all access events. The proposed system architecture combines an off-chain ZKP gateway with on-chain authorization logic to minimize blockchain overhead while preserving strong security guarantees. Furthermore, a performance evaluation framework is defined, including metrics, workload scenarios, and system configurations, to support future empirical validation. Security analysis indicates that the proposed framework enhances privacy, prevents identity linkage, and enables auditable, consent-driven data sharing compared with existing blockchain-based healthcare solutions.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Blockchain Technology Applications and Security · Blood donation and transfusion practices · Organ Donation and Transplantation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Computer Science and Engineering, Sathyabama Institute of Science and Technology, Chennai 600119, India

References (25)

Show source-provided references
1. Mani, V., Manickam, P., Alotaibi, Y., Alghamdi, S., and Khalaf, O.I. (2021). Hyperledger Healthchain: Patient-Centric IPFS-Based Storage of Health Records. Electronics, 10.10.3390/electronics10233003 ↗
2. ACHealthChain blockchain framework for access control and privacy preservation in healthcare10.1038/s41598-025-00757-1 ↗
3. Guo, H., Li, W., Nejad, M., and Shen, C.-C. (2023). A Hybrid Blockchain-Edge Architecture for Electronic Health Records Management with Attribute-based Cryptographic Mechanisms. arXiv.10.1109/TNSM.2022.3186006 ↗
4. Interoperable blockchain network for healthcare data using Fabric, Ethereum and IPFS10.1007/s44163-025-00564-7 ↗
5. PETchain: A Blockchain-Based Privacy Enhancing Technology10.1109/ACCESS.2021.3064896 ↗
6. A Hybrid Framework for Enhancing Privacy in Blockchain-Based Personal Data Sharing using Off-Chain Storage and Zero-Knowledge Proofs10.51519/journalisi.v7i2.1119 ↗
7. ProChain: A privacy-preserving blockchain-based supply chain traceability system model10.1016/j.cie.2023.109831 ↗
8. Zhao, Y., Cui, B., and Xu, J. (2022). A Privacy-Preserving Medical Data Traceability System Based on Attribute-Based Encryption on Blockchain. Communications in Computer and Information Science, Springer.10.1007/978-981-16-9229-1_2 ↗
9. Chen, C.-L., Yang, J., Tsaur, W.-J., Weng, W., Wu, C.-M., and Wei, X. (2022). Enterprise Data Sharing with Privacy-Preserved Based on Hyperledger Fabric Blockchain in IIOT’s Application. Sensors, 22.10.3390/s22031146 ↗
10. Sahu, N., Gajera, M., and Chaudhary, A. (2023). zkFi: Privacy-Preserving and Regulation Compliant Transactions using Zero Knowledge Proofs. arXiv.
11. Devi, M.B., Singh, N.C., and Singh, T.B. (2025). Zero-Knowledge Proof-Based Privacy-Preserving Smart Contracts for Healthcare. Indian Sci. J. Res. Eng. Manag., 9.10.55041/IJSREM52449 ↗
12. Blood and Product-Chain: Blood and Its Products Supply Chain Management Based on Blockchain Approach
13. Blockchain Medledger: Hyperledger fabric enabled drug traceability system for counterfeit drugs in pharmaceutical industry10.1016/j.ijpharm.2021.120235 ↗
14. Malik, S., Dedeoglu, V., Kanhere, S., and Jurdak, R. (2021). PrivChain: Provenance and Privacy Preservation in Blockchain enabled Supply Chains. arXiv.10.1109/Blockchain55522.2022.00030 ↗
15. Bai, T., Hu, Y., He, J., Fan, H., and An, Z. (2022). Health-zkIDM: A Healthcare Identity System Based on Fabric Blockchain and Zero-Knowledge Proof. Sensors, 22.10.3390/s22207716 ↗
16. Implementing zero-knowledge proof authentication on Hyperledger fabric to enhance patient privacy and access control
17. Zocca, G., and Hasan, O. (2024). Privacy-Preserving and Trustworthy Localization in an IoT Environment. arXiv, arxiv:2406.16182.
18. Azaria, A., Ekblaw, A., Vieira, T., and Lippman, A. (2016, January 22–24). MedRec: Using Blockchain for Medical Data Access and Permission Management. Proceedings of the 2016 2nd International Conference on Open and Big Data (OBD), Vienna, Austria.10.1109/OBD.2016.11 ↗
19. FHIRChain: Applying Blockchain to Securely and Scalably Share Clinical Data10.1016/j.csbj.2018.07.004 ↗
20. IoT-driven blockchain to manage the healthcare supply chain and protect medical records10.1016/j.future.2024.07.039 ↗
21. Development of Privacy-Preservation of Big Data with Support of Hyperledger Fabric and IPFS10.30534/ijatcse/2021/011052021 ↗
22. A Novel Privacy Protection Method of Residents’ Travel Trajectories Based on Federated Blockchain and InterPlanetary File Systems in Smart Cities10.7717/peerj-cs.1495 ↗
23. A Blockchain-Based Dynamic Consent Architecture to Support Clinical Genomic Data Sharing (ConsentChain): Proof-of-Concept Study10.2196/27816 ↗
24. A Blockchain-Based Personal Health Record System for Emergency Situation10.1155/2022/4941214 ↗
25. Guo, J., Zhao, K., Liang, Z., and Min, K. (2024). Efficient and Secure EMR Storage and Sharing Scheme Based on Hyperledger Fabric and IPFS. Appl. Sci., 14.10.3390/app14125005 ↗