Acute Impact of Lacticaseibacillus rhamnosus OLXAL-1 and Cistus creticus Extract on Postprandial Lipemia, Glycemia and Antioxidant Status of Healthy Adults: A Randomized, Crossover, Placebo-Controlled Clinical Trial
Source abstract
Abstract
Postprandial lipemia and glycemia are associated with nutrition-dependent diseases and cardiovascular risks, while antioxidant capacity affects blood circulation and inflammatory biomarkers. This study investigated the impact of Lacticaseibacillus rhamnosus OLXAL-1 and antioxidant intake on the above metabolic states in a randomized crossover design with three arms. Twenty-two healthy participants consumed meals consisting of bread, butter, and yogurt products (placebo or enriched with probiotics (intervention I)) or enriched with probiotics and antioxidants (intervention II). Blood samples were collected before and 30, 90, and 180 min after meal consumption, and biomarkers of lipemia, glycemia, and antioxidant status were examined. However, plasma total antioxidant capacity (TAC) was significantly greater in the combined intervention group compared to placebo (p = 0.04), with an increase of 0.24 mmol/L at 1.5 h postprandially; this effect was time-dependent (p = 0.025). In summary, the coexistence of antioxidants and probiotics showed limited acute effects on metabolic outcomes, with an increase in plasma total antioxidant capacity observed when probiotics and antioxidants were combined, while no significant changes were detected in the remaining biomarkers across intervention groups.
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Research context
OpenAlex topics: Gut microbiota and health · Probiotics and Fermented Foods · Food composition and properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Laboratory of Nutrition and Public Health, Department of Food Science and Nutrition, University of the Aegean, 81400 Myrina, Greece
Department of Food Science and Human Nutrition, Agricultural University of Athens, 11855 Athens, Greece
Outpatient Clinic, 81400 Myrina, Greece
Computer Simulation, Genomics and Data Analysis Laboratory, Department of Food Science and Nutrition, University of the Aegean, 81400 Myrina, Greece
Cardiovascular Research Centre, Department of Cardiovascular Science, University of Leicester, Leicester LE1 7RH, UK
Population, Policy and Practice Research and Teaching Department, GOS Institute of Child Health, UCL (University College London), London WC1E 6BT, UK
Laboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece
Laboratory of Organic Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
Funding
European Regional Development Fund
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