Advances in Research on the Role of Long Non-Coding RNAs in Lung Cancer Diagnosis, Treatment, and Drug Resistance
Source abstract
Abstract
Lung cancer remains a leading cause of morbidity and mortality worldwide. This review critically synthesizes recent advances on long non-coding RNAs (lncRNAs) in lung cancer. Unlike previous descriptive compilations, we provide an evidence-based analysis, distinguish preclinical from clinically validated findings (e.g., serum exosomal SNHG15, DLX6-AS1), and highlight recurring mechanistic themes (ceRNA, chromatin remodeling, m6A). We discuss inconsistencies in the literature, barriers to clinical translation (such as standardization, sample variability, and validation), and propose a roadmap for clinical integration, including how lncRNA panels could complement existing biomarkers like CYFRA21-1. A transparent literature search strategy is included.
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Research context
OpenAlex topics: Cancer-related molecular mechanisms research · RNA modifications and cancer · Lung Cancer Research Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Animal Science, Guizhou University, Guiyang 550025, China
References (100+)
Show source-provided references
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