Exploring the Therapeutic Potential of Calendula and Chamomile in Dermatology: From Anti-Inflammatory and Antioxidant Properties to New Therapeutic Perspectives
Source abstract
Abstract
Oxidative stress (OS) plays a central role in the pathogenesis of several cutaneous disorders, including inflammatory dermatoses, photoaging, and carcinogenesis. The imbalance between reactive oxygen species (ROS) production and endogenous antioxidant defenses contributes to inflammation, cellular senescence, and barrier dysfunction. Phytochemicals with antioxidant and anti-inflammatory properties have therefore gained attention as potential therapeutic agents in dermatology. Calendula officinalis (CO) and Matricaria chamomilla (MC) contain bioactive compounds, including carotenoids, flavonoids, terpenoids, and phenolic acids, that modulate redox homeostasis and inflammatory pathways. Evidence from preclinical and clinical studies indicates that CO and MC exert photoprotective effects by reducing UV-induced ROS generation and preserving dermal collagen. Both extracts promote wound healing through fibroblast stimulation, collagen deposition, and antimicrobial activity. In chronic inflammatory dermatoses, including atopic dermatitis (AD) and psoriasis (Pso), CO and MC downregulate pro-inflammatory cytokines, thereby restoring immune balance. Emerging delivery systems have enhanced their skin bioavailability and clinical effectiveness. Collectively, current data support the antioxidant, anti-inflammatory, and regenerative properties of CO and MC, underscoring their potential in maintaining skin homeostasis and protecting against oxidative damage. Further standardized, large-scale clinical studies are warranted to validate their efficacy, safety, and optimal formulations for dermatological use.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Skin Protection and Aging · Psoriasis: Treatment and Pathogenesis · Dermatology and Skin Diseases
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biomedical and Dental Science and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy
Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, 90127 Palermo, Italy
Section of Dermatology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy
Meat and Agribusiness Chain Research Consortium, Polo Universitario dell’Annunziata, Viale Giovanni Palatucci 13, 98168 Messina, Italy
Department of Agricultural, Food and Forestry Sciences, University of Palermo, 90121 Palermo, Italy
School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy
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