journal article·2025-09-05Open access

Trimester-Specific Air Pollutant Exposure During Pregnancy and Infant Neurodevelopment at One Year: Insights into the Role of Inflammation and Oxidative Stress

Jonatan A. Mendoza-Ortega, Arturo Canul-Euan, Otilia Perichart-Perera, Juan Mario Solis-Paredes, Sandra Martínez-Medina, Mariana Torres-Calapiz, Blanca Vianey Suárez-Rico, Aurora Espejel-Núñez, Araceli Montoya-Estrada, Enrique Reyes-Muñoz, Sandra Rodríguez-Martínez, Ignacio Camacho-Arroyo, Guadalupe Estrada-Gutierrez

Applied Sciences· Volume 15· Issue 17

Abstract

Prenatal exposure to air pollution is a major public health concern due to its potential to impair fetal brain development. This study examined whether maternal inflammatory and oxidative stress biomarkers mediate the association between trimester-specific air pollutant exposure during pregnancy and infant neurodevelopment at one year. We analyzed 87 mother–infant pairs from the OBESO perinatal cohort in Mexico City. Trimester-specific exposure to CO, PM10, PM2.5, SO2, and O3 was estimated using residential geolocation. Biomarkers were measured in the first and third trimesters by protocol, and intra-pregnancy change was calculated as Δ(3T–1T) for cytokines (IL-1β, IL-6, TNFα) and oxidative stress markers (malondialdehyde (MDA), protein carbonyls (PC), and total antioxidant capacity (TAC). Infant neurodevelopment at 12 months was assessed using Bayley-III. Exploratory mediation analyses were conducted, adjusting for gestational age at birth, pre-eclampsia, gestational diabetes, fetal growth restriction, marital status, mode of delivery, and infant sex; bootstrapping was applied to obtain robust estimates. Third-trimester CO exposure was associated with poorer receptive language (coef = 0.754, p = 0.02). PM2.5 exposure showed direct effects on expressive language in the first (coef = 0.01, p = 0.04) and third trimesters (coef = 0.007, p = 0.015) in models including IL-1β. Third-trimester O3 and SO2 exposures were linked to lower expressive scores in models including TNFα (coef = 0.007, p = 0.02), MDA (coef = 0.008, p = 0.04), and PC (coef = 0.007, 95% p = 0.04). Meanwhile PM10 exposure was associated with socio-emotional outcomes in models with IL-6 and TAC (coef = 0.003, p = 0.04). These findings indicate that maternal inflammation and oxidative stress biomarkers did not mediate the associations between prenatal air pollution exposure and infant neurodevelopment, and this study cannot elucidate their specific biological role in neurodevelopment.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Air Quality and Health Impacts · Climate Change and Health Impacts · Birth, Development, and Health

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Immunobiochemistry, Instituto Nacional de Perinatología, Mexico City 11000, Mexico

Departamento de Inmunología, Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Mexico City 11340, Mexico

Nutrition and Bioprogramming Coordination, Instituto Nacional de Perinatología, Mexico City 11000, Mexico

Department of Reproductive and Perinatal Health Research, Instituto Nacional de Perinatología, Mexico City 11000, Mexico

Department of Developmental Neurobiology, Instituto Nacional de Perinatología, Mexico City 11000, Mexico

Community Interventions Research Branch, Instituto Nacional de Perinatología, Mexico City 11000, Mexico

Coordination of Gynecological and Perinatal Endocrinology, Instituto Nacional de Perinatología, Mexico City 11000, Mexico

Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico

Funding

National Institute of Perinatology · FOSISS-CONACyT

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