A Flexible Frequency-Coded Electromagnetic Sensing Array for Contactless Biological Tissues Health Monitoring
Source abstract
Abstract
In this study, we present a wearable sensing system for monitoring the physiological status of damaged biological tissues based on a flexible, frequency-coded electromagnetic spiral resonator array. The physiological parameter evaluation is performed in a contactless way, avoiding the placing of electronically active elements directly upon the patient’s skin, thus ensuring safety and comfort. Firstly, we report in detail the physical principles behind the sensing strategy: a passive array is interrogated through an actively fed external single-loop probe that is inductively coupled with the double-layer spiral unit cells. The variation in the physiological parameters influences the array response, thus providing sensing information, due to the different complex dielectric permittivity values related to the tissue status. Moreover, the proposed frequency-coded approach allows for spatial information on the lesion to be retrieved, thus increasing the sensing ability. In order to prove the validity of this general methodology, we created a numerical test case, designing a practical implementation of the wearable sensing system working at a radiofrequency regime (10–100 MHz). In addition, we also fabricated prototypes, exploiting PCB technology, and realized stratified phantoms by incorporating opportune additives to control the dielectric properties. The numerical results and the experimental verification demonstrated the validity of the developed sensing strategy, showing satisfying agreement and, thus, proving the good sensibility and spatial resolution of the frequency-coded array. These results can open the path to a radically novel approach for self-care and monitoring of inflamed status and, more generally, for wearable sensing devices in biomedical applications.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Wireless Body Area Networks · Advanced Sensor and Energy Harvesting Materials · Wireless Power Transfer Systems
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Information Engineering, University of Pisa, 56122 Pisa, Italy
Consorzio Nazionale Interuniversitario per le Telecomunicazioni (C.N.I.T.), 56124 Pisa, Italy
Free Space s.r.l., via Antonio Cocchi 7, 56121 Pisa, Italy
References (51)
Show source-provided references
1. Flexible Electronics toward Wearable Sensing10.1021/acs.accounts.8b00500 ↗
2. Progress and challenges in fabrication of wearable sensors for health monitoring10.1016/j.sna.2020.112105 ↗
3. Mobile Devices and Health10.1056/NEJMra1806949 ↗
4. A Wearable Sensing System for Tracking and Monitoring of Functional Arm Movement10.1109/TMECH.2009.2039222 ↗
5. Smart bandage with wireless connectivity for optical monitoring of pH10.1016/j.snb.2017.02.095 ↗
6. Wireless Flexible Smart Bandage for Continuous Monitoring of Wound Oxygenation10.1109/TBCAS.2015.2488582 ↗
7. Wearable Sensing and Telehealth Technology with Potential Applications in the Coronavirus Pandemic10.1109/RBME.2020.2992838 ↗
8. Devi, P.D., and Ilakiya, S. (2021, January 30–31). A Secure Employee Health Management System Using Werable Technology. Proceedings of the 2021 International Conference on System, Computation, Automation and Networking (ICSCAN), Puducherry, India.10.1109/ICSCAN53069.2021.9526402 ↗
9. Early detection and monitoring of chronic wounds using low-cost, omniphobic paper-based smart bandages10.1016/j.bios.2018.06.060 ↗
10. Smart Bandages: The Future of Wound Care10.1016/j.tibtech.2018.07.007 ↗
11. Wearable Sensing Devices for Point of Care Diagnostics10.1021/acsabm.0c00798 ↗
12. Khan, S., Ali, S., and Bermak, A. (2019). Recent Developments in Printing Flexible and Wearable Sensing Electronics for Healthcare Applications. Sensors, 19.10.3390/s19051230 ↗
13. Farooqui, M.F., and Shamim, A. (2016). Low Cost Inkjet Printed Smart Bandage for Wireless Monitoring of Chronic Wounds. Sci. Rep., 6.10.1038/srep28949 ↗
14. Wearable, Human-Interactive, Health-Monitoring, Wireless Devices Fabricated by Macroscale Printing Techniques10.1002/adfm.201303874 ↗
15. Smart bandage with wireless connectivity for uric acid biosensing as an indicator of wound status10.1016/j.elecom.2015.03.018 ↗
16. Laser-enabled fabrication of flexible and transparent pH sensor with near-field communication for in-situ monitoring of wound infection10.1016/j.snb.2018.04.004 ↗
17. Wearable plasmonic-metasurface sensor for noninvasive and universal molecular fingerprint detection on biointerfaces10.1126/sciadv.abe4553 ↗
18. State of Sweat: Emerging Wearable Systems for Real-Time, Noninvasive Sweat Sensing and Analytics10.1021/acssensors.1c01133 ↗
19. Smart Bandage with Wireless Strain and Temperature Sensors and Batteryless NFC Tag10.1109/JIOT.2020.3048282 ↗
20. Bukhari, S.S., Vardaxoglou, J.Y., and Whittow, W. (2019). A Metasurfaces Review: Definitions and Applications. Appl. Sci., 9.10.3390/app9132727 ↗
21. Metasurfaces for biomedical applications: Imaging and sensing from a nanophotonics perspective10.1515/nanoph-2020-0373 ↗
22. Alsaedi, D., El Badawe, M., and Ramahi, O.M. (2021, January 4–10). A Metasurface for Biomedical Imaging Applications. Proceedings of the 2021 IEEE International Symposium on Antennas and Propagation and USNC-URSI Radio Science Meeting (APS/URSI), Singapore.10.1109/APS/URSI47566.2021.9704530 ↗
23. Flexible Metamaterial Electronics10.1002/adma.202200070 ↗
24. Flexible Mechanical Metamaterials Enabled Electronic Skin for Real-Time Detection of Unstable Grasping in Robotic Manipulation10.1002/adfm.202109109 ↗
25. A Performance-Enhanced Antenna for Microwave Biomedical Applications by Using Metasurfaces10.1109/TAP.2023.3242414 ↗
26. Rotundo, S., Brizi, D., Flori, A., Giovannetti, G., Menichetti, L., and Monorchio, A. (2022). Shaping and Focusing Magnetic Field in the Human Body: State-of-the Art and Promising Technologies. Sensors, 22.10.3390/s22145132 ↗
27. Gong, J., Seyed, T., Davis, J.U., and Yang, X.-D. (2018, January 14). Indutivo: Contact-Based, Object-Driven Interactions with Inductive Sensing. Proceedings of the 31st Annual ACM Symposium on User Interface Software and Technology, Berlin, Germany.10.1145/3242587.3242662 ↗
28. Hsieh, M.-J., Guo, J.-L., Lu, C.-Y., Hsieh, H.-W., Liang, R.-H., and Chen, B.-Y. (2019, January 17). RFTouchPads: Batteryless and Wireless Modular Touch Sensor Pads Based on RFID. Proceedings of the 32nd Annual ACM Symposium on User Interface Software and Technology, New Orleans, LA, USA.10.1145/3332165.3347910 ↗
29. Metasurfaces for bioelectronics and healthcare10.1038/s41928-021-00589-7 ↗
30. On the design of planar arrays of nonresonant coils for tunable wireless power transfer applications10.1109/TMTT.2020.2983145 ↗
31. Design of Distributed Spiral Resonators for the Decoupling of MRI Double-Tuned RF Coils10.1109/TBME.2020.2971843 ↗
32. Bioresorbable, Wireless, Passive Sensors as Temporary Implants for Monitoring Regional Body Temperature10.1002/adhm.202000942 ↗
33. Bioresorbable Wireless Sensors as Temporary Implants for In Vivo Measurements of Pressure10.1002/adfm.202003754 ↗
34. Bioresorbable, wireless, passive sensors for continuous pH measurements and early detection of gastric leakage10.1126/sciadv.adj0268 ↗
35. Arai, T., and Hirayama, H. (2020). Folded Spiral Resonator with Double-Layered Structure for Near-Field Wireless Power Transfer. Energies, 13.10.3390/en13071581 ↗
36. Design of double-layer parallel printed spiral coil for wireless power transfer applied to rotating equipment10.1016/j.sna.2021.112761 ↗
37. Millimetric Inclusion Detection Through a Contactless Microwave Spiral Sensor for Biomedical Applications10.1109/JSEN.2023.3271412 ↗
38. Using Dielectric Properties of Solid Fraction and Water Content to Characterize Tissues at Different Health and Age Conditions10.1109/JERM.2019.2952054 ↗
39. The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues10.1088/0031-9155/41/11/003 ↗
40. Accurate Extraction of Equivalent Circuit Parameters of Spiral Resonators for the Design of Metamaterials10.1109/TMTT.2018.2883036 ↗
41. Comparison of the dielectric properties of normal and wounded human skin material10.1002/bem.2250080104 ↗
42. (2025, June 10). Available online: https://www.keysight.com/it/en/product/N9918A/fieldfox-a-handheld-microwave-analyzer-26-5-ghz.html.
43. Development and characteristics of a biological tissue-equivalent phantom for microwaves10.1002/1520-6424(200104)84:4<67::AID-ECJA8>3.0.CO;2-D ↗
44. Yu, Y., Lowe, A., Anand, G., and Kalra, A. (2019, January 23–27). Tissue phantom to mimic the dielectric properties of human muscle within 20 Hz and 100 kHz for biopotential sensing ap-plications. Proceedings of the 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Berlin, Germany.10.1109/EMBC.2019.8856530 ↗
45. Materials used to simulate physical properties of human skin10.1111/srt.12235 ↗
46. Van Nunen, T., Huismans, E., Mestrom, R., Bentum, M., and Visser, H. (2019, January 18–21). DIY Electromagnetic Phantoms for Biomedical Wireless Power Transfer Experiments. Proceedings of the 2019 IEEE Wireless Power Transfer Conference (WPTC), London, UK.10.1109/WPTC45513.2019.9055704 ↗
47. Theoretical and experimental broadband tissue-equivalent phantoms at microwave and millimetre-wave frequencies10.1049/el.2014.0749 ↗
48. Synthesized tissue-equivalent dielectric phantoms using salt and polyvinylpyrrolidone solutions10.1002/mrm.27005 ↗
49. Characterization of a dielectric phantom for high-field magnetic resonance imaging applications10.1118/1.4895823 ↗
50. Alwaleedy, S., Mohemmed, S., Karale, R., Kumbharkhane, A.C., Roy, B.R., and Sarode, A.V. (2022). Study of Dielectric and Thermodynamic properties of Aqueous Glycine. Review.10.21203/rs.3.rs-1916869/v1 ↗
51. Lu, Y., Yang, W., Wang, Y., Fan, Q., Duan, X., and Xie, M. (2022, January 16–18). Spiral Resonator-based Corneal Contact Lens For Intraocular Pressure Monitoring. Proceedings of the 2022 28th International Conference on Mechatronics and Machine Vision in Practice (M2VIP), Nanjing, China.10.1109/M2VIP55626.2022.10041067 ↗