journal article·2025-08-04Open access

Cytotoxicity Evaluation of Cyprodinil, Potentially Carcinogenic Chemical Micropollutant, for Oxidative Stress, Apoptosis and Cell Membrane Interactions

Agata Jabłońska-Trypuć, Nina Wiśniewska, Gabriela Sitko, Urszula Wydro, Elżbieta Wołejko, Rafał Krętowski, Monika Naumowicz, Joanna Kotyńska, Marzanna Cechowska-Pasko, Bożena Łozowicka, Piotr Kaczyński, Adam Cudowski

Applied Sciences· Volume 15· Issue 15

Abstract

Fungicides are compounds with potentially toxic effects on the human body, but the molecular mechanisms of their action have not yet been explained. The effect of cyprodinil on cell viability, apoptosis level, cell membrane function, cell morphology and expression of antioxidant enzyme genes in the A-375 and DLD-1 cell lines was examined. The cell lines were selected because they can be an excellent in vitro model of neoplastic changes occurring in the skin and large intestine after exposure to a fungicide. The fungicide selected for the study is commonly used in Poland to protect crops against fungi. Our results showed that the tested compound increased cell viability and proliferation, probably activated by mechanisms related to oxidative stress. Cyprodinil caused an increase in glutathione level (in A-375 by about 37% and in DLD-1 by about 28%) and oxidative stress enzymes activity, but not in apoptosis level. Its membrane interactions and its penetration into cells was concentration dependent. It is worth emphasizing that the novelty of our work lies in the use of non-traditional toxicological methods based on molecular analyses using human cell lines. This allowed us to demonstrate not only the toxicity of a single substance but also its behavior within cellular structures. Our findings suggest that cyprodinil may have tumor-promoting properties in skin and colorectal cancer cells.
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Research context

OpenAlex topics: Pesticide and Herbicide Environmental Studies · Carcinogens and Genotoxicity Assessment · Pesticide Exposure and Toxicity

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, Biology and Biotechnology, Faculty of Civil Engineering and Environmental Sciences, Bialystok University of Technology, Wiejska 45E Street, 15-351 Białystok, Poland

Department of Pharmaceutical Biochemistry, Medical University of Bialystok, Mickiewicza 2A Street, 15-222 Bialystok, Poland

Department of Physical Chemistry, Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K Street, 15-245 Bialystok, Poland

Institute of Plant Protection—National Research Institute, Chełmońskiego 22 Street, 15-195 Białystok, Poland

Department of Water Ecology, Faculty of Biology, University of Białystok, Ciołkowskiego 1J Street, 15-245 Białystok, Poland

Funding

Ministry of Education and Science, Poland

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