Gait Kinematics of Individuals with SYNGAP1-Related Disorder Compared with Age-Matched Neurotypical Individuals
Source abstract
Abstract
SYNGAP1-related disorder is a rare neurodevelopmental disorder characterized by intellectual and motor disabilities, including disordered gait control. Currently, there have been few studies that have assessed the gait of individuals with SYNGAP1-related disorder using technology-based collection techniques. The purpose of this investigation was to characterize the kinematic gait pattern of these individuals using camera-based motion capture technology during treadmill walking. Both linear and non-linear analysis techniques were used to analyze bilateral lower-limb joint motion and compare the results to age-matched neurotypical individuals. Results indicate that joint range of motion and velocity were decreased in the patient population relative to the neurotypical participants with the non-linear measures of angle–angle and phase portrait areas reflecting similar outcomes. The combination of linear and non-linear measures provide complementary information that, when used in combination, can provide deeper insights into the coordination and control of gait than if either of the measurement techniques are used in isolation. Such information can be useful to clinicians and therapists to develop targeted interventions designed to improve the gait of individuals with SYNGAP1-related disorder.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Genetics and Neurodevelopmental Disorders · Mitochondrial Function and Pathology · Cellular transport and secretion
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Center for Neuromotor and Biomechanics Research, Houston, TX 77204, USA
Department of Health and Human Performance, University of Houston, Houston, TX 77204, USA
Grail Laboratory, Parker University, Dallas, TX 75229, USA
Blue Bird Circle Rett Center, Texas Children’s Hospital, Houston, TX 77030, USA
Departments of Pediatrics and Neurology, Baylor College of Medicine, Houston, TX 77030, USA
Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030, USA
Funding
SYNGAP1 Foundation
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