Systematic Review and Meta-Analysis of Melatonin Quantification in Wine
Source abstract
Abstract
The identification of melatonin in grapes has led to the publication of numerous studies on melatonin in wines, and the aim of this study was to perform a systematic review and meta-analysis of published data on melatonin concentrations in wines. In this context, international databases such as Scopus, Web of Science and PubMed were searched for relevant articles (437) up to 29 March 2025. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used. A total of 15 studies from eight countries, involving various wine types and analytical methods, were included in the meta-analysis. Considerable analytical variation was observed across studies, and high-performance liquid chromatography (HPLC) coupled with either mass spectrometry (MS) or fluorescence (FL) detection was shown to be the most accurate and sensitive method for quantifying melatonin. The highest concentrations were found in Spanish red Tempranillo wine, Romanian white Noah wine, and Romanian rosé Lidia wine. Red wines, particularly those produced from Cabernet Sauvignon (CS) grapes, were the most frequently studied. The results of this work provide a clearer picture of melatonin levels in wine. Further research is needed to explore the implications of melatonin content in wine for human health and the wine industry.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Fermentation and Sensory Analysis · Horticultural and Viticultural Research · Plant and animal studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Centre of Bioanalysis, National Institute of Research and Development for Biological Sciences–Bucharest, 296 Splaiul Independentei, 060031 Bucharest, Romania
Funding
The Ministry of Research, Innovation and Digitalization
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