Labeling Peptides with Radioiodine: An Overview of Traditional and Emerging Techniques
Source abstract
Abstract
This review focuses on the synthetic methodologies for radioiodinating peptides, a crucial process for developing effective radiopharmaceuticals used in diagnostics and therapeutics. We explore direct and indirect radioiodination methods, including mechanisms, reaction conditions, and purification strategies. The focus is on the chemical approaches that enable radioiodine incorporation into peptide structures, considering the challenges of maintaining peptide integrity and biological activity. This article is intended as a detailed resource for understanding traditional approaches and recent chemical developments in radioiodination.
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Research context
OpenAlex topics: Radiopharmaceutical Chemistry and Applications · Medical Imaging Techniques and Applications · Chemical Reactions and Isotopes
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Drug and Health Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy
Department of Biomedical and Biotechnological Sciences (Biometec), University of Catania, Via Santa Sofia 97, 95123 Catania, Italy
Department of Neurofarba—Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy
Department of Health Sciences, University Magna Graecia, 88100 Catanzaro, Italy
Funding
PRIN 2022
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