Beam Dynamics Design of a Multi-Ion RFQ for Medical Application
Source abstract
Abstract
Particle radiotherapy based on the medical accelerator is emerging as a major treatment for cancer. To enhance the clinical flexibility of particle radiotherapy and further promote the use of medical accelerators, the Shanghai Institute of Applied Physics (SINAP) has presented a new linear accelerator plan for medical application. The new plan utilizes a 200 MHz Radio Frequency Quadrupole (RFQ) as the injector. The RFQ is designed to accelerate ions with charge-to-mass ratios of 1/3 to 1/2 from 8 keV/u to 750 keV/u. For the beam dynamics design, a new design strategy is presented to enhance the suppression of space charge effects and improve beam capture efficiency by optimizing the modulation, synchronous phase, and focusing strength. The simulation results demonstrate that the multi-ion RFQ can operate at a maximum beam current of 3.2 mA while maintaining a transmission efficiency above 95% with a compact length of 2.5 m. Multi-particle simulations confirm the high reliability of the design. Additionally, input and mechanical error analyses evaluate the RFQ’s tolerance and stability. The research results demonstrate the feasibility of a compact, high-efficiency RFQ for multi-ion acceleration in medical applications, contributing to the advancement of particle therapy.
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Research context
OpenAlex topics: Particle accelerators and beam dynamics · Radiation Therapy and Dosimetry · Particle Accelerators and Free-Electron Lasers
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
University of Chinese Academy of Sciences, Beijing 100049, China
Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China
Funding
Shanghai Advanced Research Institute, Chinese Academy of Sciences
References (55)
Show source-provided references
1. Basics of particle therapy i: Physics10.3857/roj.2011.29.3.135 ↗
2. Nuclear physics in particle therapy: A review10.1088/0034-4885/79/9/096702 ↗
3. Particle therapy at the heidelberg ion therapy center (hit)—Integrated research-driven university-hospital-based radiation oncology service in heidelberg, germany10.1016/j.radonc.2010.02.016 ↗
4. Recent progress and future plans of heavy-ion cancer radiotherapy with himac10.1016/j.nimb.2017.04.021 ↗
5. Carbon ion radiotherapy at the gunma university heavy ion medical center: New facility set-up10.3390/cancers3044046 ↗
6. Design of a compact structure cancer therapy synchrotron10.1016/j.nima.2014.04.050 ↗
7. Inaniwa, T., Kanematsu, N., Noda, K., and Kamada, T. (2017). Treatment planning of intensity modulated composite particle therapy with dose and linear energy transfer optimization. Phys. Med. Biol., 62.10.1088/1361-6560/aa68d7 ↗
8. Kopp, B., Mein, S., Dokic, I., Harrabi, S., Böhlen, T.T., Haberer, T., Debus, J., Abdollahi, A., and Mairani, A. (2020). Development and validation of single field multi-ion particle therapy treatments. Int. J. Radiat. Oncol. Biol. Phys., 106.10.1016/j.ijrobp.2019.10.008 ↗
9. Ebner, D.K., Frank, S.J., Inaniwa, T., Yamada, S., and Shirai, T. (2021). The emerging potential of multi-ion radiotherapy. Front. Oncol., 11.10.3389/fonc.2021.624786 ↗
10. Wangler, T.P. (2008). RF Linear Accelerators, John Wiley & Sons.10.1002/9783527623426 ↗
11. Ratzinger, U., Peters, A., Zhang, C., Hähnel, H., Hoeltermann, H., Podlech, H., Schuett, M., Cee, R., Altürk, S., and Haberer, T. (2024, January 25–30). A new rfq for the carbon therapy injector at hit heidelberg. Proceedings of the 32nd Linear Accelerator Conference (LINAC2024), Chicago, IL, USA.
12. Design study of compact medical accelerator using superconducting rf quadrupole for boron neutron capture therapy10.1103/PhysRevAccelBeams.25.021601 ↗
13. 750 mhz radio frequency quadrupole with trapezoidal vanes for carbon ion therapy10.1103/PhysRevAccelBeams.23.122003 ↗
14. Carbon ion injection system for a complex of radiation therapy10.1134/S1547477124700237 ↗
15. Yap, J., Franco, A.D., and Sheehy, S. (2021). Future developments in charged particle therapy: Improving beam delivery for efficiency and efficacy. Front. Oncol., 11.10.3389/fonc.2021.780025 ↗
16. Emerging technologies for cancer therapy using accelerated particles10.1016/j.ppnp.2023.104046 ↗
17. Technological developments and future perspectives in particle therapy: A topical review10.1109/TRPMS.2024.3372189 ↗
18. Fast-bunching design of compact heavy ion rfq linac10.1007/s41365-018-0514-x ↗
19. Improved bunching and longitudinal emittance control in an rfq10.1088/1748-0221/17/12/P12011 ↗
20. Vretenar, M., Dallocchio, A., Dimov, V., Garlaschè, M., Grudiev, A., Lombardi, A., Mathot, S., Montesinos, E., and Timmins, M. (September, January 31). A compact high-frequency rfq for medical applications. Proceedings of the 27th Linear Accelerator Conference, LINAC2014, Geneva, Switzerland.
21. Beam dynamics design and error analysis of a high frequency rfq for medical application10.1016/j.nima.2024.169930 ↗
22. Radial matching section of rfq revisited10.1088/1748-0221/15/10/T10001 ↗
23. Jacow: Conceptual design of a compact synchrotron-based facility for cancer therapy and biomedical research with helium and proton beams
24. New accelerator designs: Nimms10.1007/s12553-024-00882-3 ↗
25. Organization and operation of multi particle therapy facilities: The marburg ion-beam therapy center, germany (mit)10.1007/s12553-024-00881-4 ↗
26. Criterion for vacuum sparking designed to include both rf and dc10.1063/1.1715731 ↗
27. Innovations in the next generation medical accelerators for therapy with ion beams10.1088/1742-6596/2687/9/092003 ↗
28. Mairani, A., Mein, S., Blakely, E., Debus, J., Durante, M., Ferrari, A., Fuchs, H., Georg, D., Grosshans, D.R., and Guan, F. (2022). Roadmap: Helium ion therapy. Phys. Med. Biol., 67.10.1088/1361-6560/ac65d3 ↗
29. Suzuki, M., Kase, Y., Yamaguchi, H., Kanai, T., and Ando, K. (2000). Relative biological effectiveness for cell-killing effect on various human cell lines irradiated with heavy-ion medical accelerator in chiba (himac) carbon-ion beams. Int. J. Radiat. Oncol. Biol. Phys., 48.10.1016/S0360-3016(00)00568-X ↗
30. Helium ions for radiotherapy? physical and biological verifications of a novel treatment modality10.1118/1.4944593 ↗
31. Performance of a compact injector for heavy-ion medical accelerators10.1016/j.nima.2007.01.012 ↗
32. Vormann, H., Schlitt, B., Clemente, G., Kleffner, C., Reiter, A., and Ratzinger, U. (2008, January 23–27). Status of the linac components for the italian hadrontherapy centre cnao. Proceedings of the 11th European Conference, EPAC 2008, Genoa, Italy.
33. Rf design of radio-frequency quadrupole accelerator for heavy ion medical machine10.1016/j.nima.2019.02.045 ↗
34. Development of an rfq-based compact accelerator system for ion beam applications10.1007/s40042-023-00836-4 ↗
35. Crandall, K.R. (1836). RFQ Design Codes, LANL Report, Los Alamos National Laboratory. Available online: https://scholar.google.com/scholar?hl=zh-CN&as_sdt=0%2C5&q=Crandall%2C+K.%3B+et+al.+Rfq+Design+Codes%2C+Lanl+Report%3B+Tech.+Rep.+LA-UR-96+%281836%29&btnG=#d=gs_cit&t=1748577274374&u=%2Fscholar%3Fq%3Dinfo%3A_wYCjdUns2QJ%3Ascholar.google.com%2F%26output%3Dcite%26scirp%3D0%26hl%3Dzh-CN.
36. Crandall, K., Stokes, R., and Wangler, T. (1979, January 10–14). Rf quadrupole beam dynamics design studies. Proceedings of the Linear Accelerator Conference, Montauk, NY, USA.
37. Beam dynamics studies on a 200 ma proton radio frequency quadrupole accelerator10.1016/j.nima.2007.12.001 ↗
38. Bahng, J., Choi, B.H., Choi, B.-H., Kim, D., and Kim, E.-S. (2017, January 14–19). Development of rfq for bnct accelerator. Proceedings of the 8th International Particle Accelerator Conference (IPAC’17), Copenhagen, Denmark.
39. Kondo, Y., Tamura, J., and Yee-Rendon, B. (2019, January 23–27). Reference design of the rfq for jaea ads linac. Proceedings of the 3rd J-PARC Symposium (J-PARC2019), Tsukuba, Japan.
40. Beam dynamics and electromagnetic design studies of 3 mev rfq for sns programme
41. Design studies of a high-current radiofrequency quadrupole for accelerator-driven systems programme10.1007/s12043-010-0024-9 ↗
42. Optimization of a radial matching section10.1142/S0217751X09044413 ↗
43. Design of an upgradeable 45–100 ma rfq accelerator for fair10.1016/j.nima.2009.08.051 ↗
44. Yaramyshev, S., Barth, W., Maier, M., Orzhekhovskaya, A., Schlitt, B., Vormann, H., Cee, R., and Peters, A. (2009, January 8–12). Upgrade of the hit injector linac-frontend . Proceedings of the 11th International Conference on Heavy Ion Accelerator Technology (HIAT’09), Venice, Italy.
45. Davidson, R.C., and Hong, Q. (2001). Physics of Intense Charged Particle Beams in High Energy Accelerators, World Scientific.10.1142/p250 ↗
46. Reiser, M. (2008). Theory and Design of Charged Particle Beams, John Wiley & Sons.10.1002/9783527622047 ↗
47. Comparison of longitudinal emittance of various rfqs10.1088/1748-0221/19/01/P01024 ↗
48. Kumar, S., and Mandal, A. (2015, January 3–8). Start to end simulation of high current injector using tracewin code. Proceedings of the 6th International Particle Accelerator Conference (IPAC2015), Richmond, VA, USA. MOPWA047.
49. Toutatis: A radio frequency quadrupole code10.1103/PhysRevSTAB.3.124201 ↗
50. Impact of ion source stability for a medical accelerator10.1088/1748-0221/14/05/C05017 ↗
51. Sen, T., and Syphers, M. (1993, January 17–20). Effect of power supply ripple on emittance growth in the collider. Proceedings of the International Conference on Particle Accelerators, Washington, DC, USA.
52. An all permanent magnet electron cyclotron resonance ion source for heavy ion therapy10.1063/1.4852335 ↗
53. Space-charge limits in heavy-ion rfq linacs
54. Crandall, K.R., Wangler, T.P., Young, L.M., Billen, J.H., Neuschaefer, G.H., and Schrage, D.L. (2005). RFQ Design Codes, Los Alamos National Laboratory. LA-UR-96-1836.
55. Eshraqi, M., Prisco, R.D., Miyamoto, R., Edgar, S., and Dølrath, T.H. (2014, January 15–20). Statistical error studies in the ess linac. Proceedings of the 5th International Particle Accelerator Conference, IPAC 2014, Dresden, Germany.