Photoacoustic Imaging with a Finite-Size Circular Integrating Detector
Source abstract
Abstract
Photoacoustic imaging (PAI) has rapidly developed in biomedical imaging. The point spread function (PSF) is critical for addressing image blurring in PAI. However, in circular integrating detection systems, the PSF exhibits spatial variations. This makes PSF extraction challenging. The existing studies typically assume that the PSF is known or obtained through experiments. This study proposes a method for extracting the PSF based on the polar coordinate system. By transforming the image from the Cartesian coordinate system to the polar coordinate system, the “spin blur” problem is decomposed into multiple independent subproblems. With the separation of the radial and angular directions, the blurring kernel remains invariant at each radius, thereby simplifying the estimation of the PSF. To estimate the blurring kernel, we use polynomial algebraic common factor extraction techniques. The numerical simulation results validate the effectiveness of the method, and the impact of sample size on computational efficiency and accuracy is discussed.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Photoacoustic and Ultrasonic Imaging · Thermography and Photoacoustic Techniques · Nanoplatforms for cancer theranostics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Metastable Materials Science & Technology and Key Laboratory for Microstructural Material Physics of Hebei Province, School of Science, Yanshan University, Qinhuangdao 066004, China
Funding
National Natural Science Foundation of China
References (36)
Show source-provided references
1. Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs10.1126/science.1216210 ↗
2. Progress in Biomedical Photoacoustic Imaging Instrumentation toward Clinical Application10.1063/5.0028190 ↗
3. Optoacoustic Imaging of Blood for Visualization and Diagnostics of Breast Cancer10.1117/12.469851 ↗
4. Ermilov, S.A., Khamapirad, T., Conjusteau, A., Leonard, M.H., Lacewell, R., Mehta, K., Miller, T., and Oraevsky, A.A. (2009). Laser Optoacoustic Imaging System for Detection of Breast Cancer. J. Biomed. Opt., 14.10.1117/1.3086616 ↗
5. Three-Dimensional Photoacoustic Imaging of Blood Vessels in Tissue10.1364/OL.23.000648 ↗
6. Noninvasive Laser-Induced Photoacoustic Tomography for Structural and Functional in Vivo Imaging of the Brain10.1038/nbt839 ↗
7. Li, C., and Wang, L.V. (2009). Photoacoustic Tomography of the Mouse Cerebral Cortex with a High-Numerical-Aperture-Based Virtual Point Detector. J. Biomed. Opt., 14.10.1117/1.3122365 ↗
8. Serial Noninvasive Photoacoustic Imaging of Neovascularization in Tumor Angiogenesis10.1364/OPEX.13.000089 ↗
9. Design and Evaluation of a Novel Breast Cancer Detection System Combining Both Thermoacoustic (TA) and Photoacoustic (PA) Tomography10.1118/1.2911157 ↗
10. Initial Results of in Vivo Non-Invasive Cancer Imaging in the Human Breast Using near-Infrared Photoacoustics10.1364/OE.15.012277 ↗
11. Song, K.H., Stein, E.W., Margenthaler, J.A., and Wang, L.V. (2008). Noninvasive Photoacoustic Identification of Sentinel Lymph Nodes Containing Methylene Blue in Vivo in a Rat Model. J. Biomed. Opt., 13.10.1117/1.2976427 ↗
12. Sentinel Lymph Nodes in the Rat: Noninvasive Photoacoustic and US Imaging with a Clinical US System10.1148/radiol.10091772 ↗
13. Near Infrared Photoacoustic Detection of Sentinel Lymph Nodes with Gold Nanobeacons10.1016/j.biomaterials.2010.01.136 ↗
14. In Vivo Carbon Nanotube-Enhanced Non-Invasive Photoacoustic Mapping of the Sentinel Lymph Node10.1088/0031-9155/54/11/001 ↗
15. Gold Nanorod–Assisted Theranostic Solution for Nonvisible Residual Disease in Bladder Cancer10.1073/pnas.2411583121 ↗
16. Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications10.1002/adma.201805875 ↗
17. Upputuri, P.K., and Pramanik, M. (2020). Recent Advances in Photoacoustic Contrast Agents for in Vivo Imaging. WIREs Nanomed. Nanobiotechnol., 12.10.1002/wnan.1618 ↗
18. Circular Integrating Detectors in Photo and Thermoacoustic Tomography10.1080/17415970802166782 ↗
19. Grun, H., Paltauf, G., Haltmeier, M., and Burgholzer, P. (2007). Photoacoustic Tomography Using a Fiber Based Fabry-Perot Interferometer as an Integrating Line Detector and Image Reconstruction by Model-Based Time Reversal Method. Novel Optical Instrumentation for Biomedical Applications III, Proceedings of the European Conference on Biomedical Optics, Munich, Germany, 17–21 June 2007, Optica Publishing Group.10.1364/ECBO.2007.6631_6 ↗
20. Universal Back-Projection Algorithm for Photoacoustic Computed Tomography10.1103/PhysRevE.71.016706 ↗
21. Photoacoustic Tomography in Absorbing Acoustic Media Using Time Reversal10.1088/0266-5611/26/11/115003 ↗
22. Roitner, H., Haltmeier, M., Nuster, R., O’Leary, D.P., Berer, T., Paltauf, G., Grün, H., and Burgholzer, P. (2014). Deblurring Algorithms Accounting for the Finite Detector Size in Photoacoustic Tomography. J. Biomed. Opt, 19.10.1117/1.JBO.19.5.056011 ↗
23. Oraevsky, A.A., and Wang, L.V. (2010). Reconstruction of Photoacoustic Tomography with Finite-Aperture Detectors: Deconvolution of the Spatial Impulse Response. Photons Plus Ultrasound: Imaging and Sensing 2010, SPIE.
24. Investigation of the Far-Field Approximation for Modeling a Transducer’s Spatial Impulse Response in Photoacoustic Computed Tomography10.1016/j.pacs.2013.11.001 ↗
25. Luo, X., Xiao, J., Wang, C., and Wang, B. (2021). Fast Correction of “Finite Aperture Effect” in Photoacoustic Tomography Based on Spatial Impulse Response. Photonics, 8.10.3390/photonics8090356 ↗
26. Song, X., Song, L., Chen, A., and Wei, J. (2010). Deconvolution Optical-Resolution Photoacoustic Microscope for High-Resolution Imaging of Brain. SPIE Future Sensing Technologies, SPIE.
27. Photoacoustic Tomography Image Restoration with Measured Spatially Variant Point Spread Functions10.1109/TMI.2021.3077022 ↗
28. Image Restoration for Ring-Array Photoacoustic Tomography System Based on Blind Spatially Rotational Deconvolution10.1016/j.pacs.2024.100607 ↗
29. Photoacoustic Imaging with Deconvolution Algorithm10.1088/0031-9155/49/14/006 ↗
30. Spatial Resolution in Photoacoustic Tomography: Effects of Detector Size and Detector Bandwidth10.1088/0266-5611/26/12/125002 ↗
31. Analytic Explanation of Spatial Resolution Related to Bandwidth and Detector Aperture Size in Thermoacoustic or Photoacoustic Reconstruction10.1103/PhysRevE.67.056605 ↗
32. Euclid and the Art of Wavelet Estimation, Part I: Basic Algorithm for Noise−free Data10.1190/1.1444293 ↗
33. Weighted Linear Least Squares Estimation of Diffusion MRI Parameters: Strengths, Limitations, and Pitfalls10.1016/j.neuroimage.2013.05.028 ↗
34. Cubic Convolution Interpolation for Digital Image Processing10.1109/TASSP.1981.1163711 ↗
35. Treeby, B.E., and Cox, B.T. (2010). K-Wave: MATLAB Toolbox for the Simulation and Reconstruction of Photoacoustic Wave Fields. J. Biomed. Opt., 15.10.1117/1.3360308 ↗
36. Lou, Y., Zhou, W., Matthews, T.P., Appleton, C.M., and Anastasio, M.A. (2017). Generation of Anatomically Realistic Numerical Phantoms for Photoacoustic and Ultrasonic Breast Imaging. J. Biomed. Opt, 22.10.1117/1.JBO.22.4.041015 ↗