Wrinkle Improvement in HanDam (Twist) on Ultraviolet B Irradiation-Induced Skin Photoaging in Hairless Mice
Source abstract
Abstract
Background: Skin photoaging caused by ultraviolet B (UV-B) irradiation leads to the formation of wrinkles. A method to lessen wrinkles is the application of Polydioxanone (PDO) lifting threads. HanDam (Twist) is a PDO lifting thread with a unique morphological twisted shape. Objective: The aim of this study was to evaluate the wrinkle improvement ability of HanDam (Twist) on UV-B irradiation-induced skin photoaging in a hairless mouse model. Methods: Wrinkles were induced by UV-B irradiation to the backs of female hairless mice for six weeks. After induction, the wrinkles were treated with threads, and the mice were monitored for six weeks post-treatment. Results: Our results showed that treatment with HanDam (Twist) effectively ameliorated UV-B irradiation-induced wrinkle depth and significantly increased collagen density by 13% compared to HanDam (non-Twist) in the histological analysis. In measuring protein expression related to collagen production, HanDam (Twist) significantly increased transforming growth factor beta (TGF-β) and collagen type 1 (COL1) by 46% and 67% compared to HanDam (non-Twist). Matrix metalloproteinase-1 (MMP-1) protein expression showed similar density and no significance compared to HanDam (non-Twist). Conclusions: These findings suggest that HanDam (Twist) improves the effectiveness of lifting threads for skin care compared to that of existing products.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Skin Protection and Aging · melanin and skin pigmentation · Olfactory and Sensory Function Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Laboratory Animal Medicine, College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-ro, Iksan-si 54596, Republic of Korea
Plastic Material R&D Center, OSSTEM IMPLANT, Magokjungang 12-ro 3, Gangseo-gu, Seoul 07522, Republic of Korea
References (38)
Show source-provided references
1. Choi, S.I., Han, H.S., Kim, J.M., Park, G., Jang, Y.P., Shin, Y.K., Ahn, H.S., Lee, S.H., and Lee, K.T. (2021). Eisenia bicyclis Extract Repairs UVB-Induced Skin Photoaging In Vitro and In Vivo: Photoprotective Effects. Mar. Drugs, 19.10.3390/md19120693 ↗
2. Photochemoprevention of ultraviolet B signaling and photocarcinogenesis10.1016/j.mrfmmm.2004.07.019 ↗
3. Transmission of human epidermis and stratum corneum as a function of thickness in the ultraviolet and visible wavelengths10.1111/j.1751-1097.1984.tb04622.x ↗
4. Ultraviolet light and dendritic cells
5. Ultraviolet B regulation of transcription factor families: Roles of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) in UVB-induced skin carcinogenesis10.2174/156800907780809714 ↗
6. Pathophysiology of premature skin aging induced by ultraviolet light10.1056/NEJM199711133372003 ↗
7. Enzyme-modified Panax ginseng inhibits UVB-induced skin aging through the regulation of procollagen type I and MMP-1 expression10.1039/C3FO60418G ↗
8. The chromene sargachromanol E inhibits ultraviolet A-induced ageing of skin in human dermal fibroblasts10.1111/bjd.12187 ↗
9. Thread Embedding Acupuncture Inhibits Ultraviolet B Irradiation-Induced Skin Photoaging in Hairless Mice10.1155/2015/539172 ↗
10. Modulation of skin collagen metabolism in aged and photoaged human skin in vivo10.1046/j.0022-202x.2001.01544.x ↗
11. Inhibition of type I procollagen production in photodamage: Correlation between presence of high molecular weight collagen fragments and reduced procollagen synthesis10.1046/j.1523-1747.2002.01810.x ↗
12. Ultraviolet irradiation increases matrix metalloproteinase-8 protein in human skin in vivo10.1046/j.0022-202x.2001.01432.x ↗
13. Lasers for facial rejuvenation: A review10.1046/j.1365-4362.2003.01784.x ↗
14. Hyaluronic acid-based fillers: Theory and practice10.1016/j.clindermatol.2007.09.001 ↗
15. Global Aesthetics Consensus: Botulinum Toxin Type A-Evidence-Based Review, Emerging Concepts, and Consensus Recommendations for Aesthetic Use, Including Updates on Complications10.1097/01.prs.0000475758.63709.23 ↗
16. Investigation on the Cutaneous Change Induced by Face-Lifting Monodirectional Barbed Polydioxanone Thread10.1097/DSS.0000000000000925 ↗
17. Update on treatment rationale and options for the ageing face10.1097/MOO.0b013e328348c1cb ↗
18. Retinoids in the treatment of skin aging: An overview of clinical efficacy and safety10.2147/ciia.2006.1.4.327 ↗
19. APTOS suture lifting methods: 10 years of experience10.1016/j.cps.2008.12.003 ↗
20. SMAS repositioning technique utilizing cog thread: Anatomical perspectives10.1111/srt.13650 ↗
21. Comparison of Antiaging Effects on Rat Skin of Cog Thread and Poly-L-Lactic Acid Thread10.1097/DSS.0000000000001717 ↗
22. Hong, G.W., Hu, H.W., Park, S.Y., Wan, J., and Yi, K.H. (2024). What Are the Factors That Enable Thread Lifting to Last Longer?. Cosmetics, 11.10.3390/cosmetics11020042 ↗
23. Efficacy study of the new polycaprolactone thread compared with other commercialized threads in a murine model10.1111/jocd.13883 ↗
24. The effects and mechanism of collagen peptide and elastin peptide on photoaging of skin cells induced by ultraviolet radiation
25. Zheng, S.-L., Wang, Y.-M., Chi, C.-F., and Wang, B. (2024). Chemical Characterization of Honeysuckle Polyphenols and Their Alleviating Function on Ultraviolet B-Damaged HaCaT Cells by Modulating the Nrf2/NF-κB Signaling Pathways. Antioxidants, 13.10.3390/antiox13030294 ↗
26. Evaluating the glucose tolerance test in mice10.1152/ajpendo.90617.2008 ↗
27. Photoaging of the skin from phenotype to mechanisms10.1016/S0531-5565(00)00098-X ↗
28. Kang, M.K., Kim, D.Y., Oh, H., Kim, S.I., Oh, S.Y., Na, W., Park, S.H., Park, K., Kim, J.I., and Kim, A.H. (2021). Dietary Collagen Hydrolysates Ameliorate Furrowed and Parched Skin Caused by Photoaging in Hairless Mice. Int. J. Mol. Sci., 22.10.3390/ijms22116137 ↗
29. Shin, S.H., Lee, Y.H., Rho, N.K., and Park, K.Y. (2023). Skin aging from mechanisms to interventions: Focusing on dermal aging. Front. Physiol., 14.10.3389/fphys.2023.1195272 ↗
30. Resveratrol Treats UVB-Induced Photoaging by Anti-MMP Expression, through Anti-Inflammatory, Antioxidant, and Antiapoptotic Properties, and Treats Photoaging by Upregulating VEGF-B Expression10.1155/2022/6037303 ↗
31. Exosomes derived from human adipose mesenchymal stem cells attenuate hypertrophic scar fibrosis by miR-192-5p/IL-17RA/Smad axis10.1186/s13287-021-02290-0 ↗
32. Enhancing structural support of the dermal microenvironment activates fibroblasts, endothelial cells, and keratinocytes in aged human skin in vivo10.1038/jid.2012.364 ↗
33. Expression of transforming growth factor-β after different non-invasive facial rejuvenation modalities10.1111/ijd.12435 ↗
34. Comparative effects of various absorbable threads in a rat model10.1080/14764172.2018.1493511 ↗
35. Facial rejuvenation and improvement of malar projection using sutures with absorbable cones: Surgical technique and case series10.1007/s00266-010-9570-2 ↗
36. Subcutaneous tissue fibroblast cytoskeletal remodeling induced by acupuncture: Evidence for a mechanotransduction-based mechanism10.1002/jcp.20623 ↗
37. Mechanical signaling through connective tissue: A mechanism for the therapeutic effect of acupuncture10.1096/fj.01-0015hyp ↗
38. Mechanical stimulation increases collagen type I and collagen type III gene expression of stem cell-collagen sponge constructs for patellar tendon repair10.1089/ten.2006.0339 ↗