Exposure of Xenogeneic Biomaterial to the Oral Environment and Its Impact on Tissue Healing of Immediate Dental Implants: A Case–Control Study
Source abstract
Abstract
This study evaluated the clinical and tomographic outcomes of socket healing. Immediate implants were placed in the molar area, and the gap was filled with either deproteinized bovine bone mineral (B) or collagen matrix (BM), n = 14/group. Scores of epithelization healing, immunoassay for VEGF, IL-1β, and FGF from wound exudate, keratinized mucosa variation (ΔKM), and bone levels were evaluated. The B group had slower tissue maturation than BM (p < 0.05), but gingival epithelialization was similar (p > 0.05). At the restorative phase, the B group exhibited greater ΔKM at prosthesis installation—1 to 2 months of postoperative (increase of 0.29 mm) compared to the BM group (reduction of −1.5 mm) (p < 0.05). Inflammatory tissue responses as well as vertical and horizontal bone remodeling were similar (p > 0.05). Crestal bone remodeling was limited to less than 0.8 mm for both groups. Taken together, the B and BM groups behaved similarly and promoted stable conditions for biomaterial incorporation in the socket healing after immediate implant placement in molar areas.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Dental Implant Techniques and Outcomes · Dental materials and restorations · Dental Radiography and Imaging
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Oral Surgery and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo—USP, Avenida do Café S/N, Ribeirao Preto 14040-904, Brazil
Independent Researcher, Private Practice, Aracaju 49015-230, Brazil
Department of Basic Sciences, School of Dentistry of Araçatuba, São Paulo State University Júlio de Mesquita Filho—UNESP, Araçatuba 16015-050, Brazil
Health Sciences Graduate Program, Federal University of Sergipe, Cláudio Batista Street, 505, Palestina, Aracaju 49060-108, Brazil
Funding
São Paulo Research Foundation—FAPESP, Research Project
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