The Essential Role of Monte Carlo Simulations for Lung Dosimetry in Liver Radioembolization—Part B: 166Ho Microspheres
Source abstract
Abstract
This study compares dosimetric approaches for lung dosimetry in 166 radioembolization (Ho-TARE) with direct Monte Carlo (MC) simulations on a voxelized anthropomorphic phantom derived from a real patient’s CT scan, preserving the patient’s lung density distribution. Lung dosimetry was assessed for five lung shunt (LS) scenarios with conventional methods: the mono-compartmental organ-level approach (MIRD), voxel S-value convolution for soft tissue (kST, ICRU soft tissue with 1.04 g/cm3) and lung tissue (kLT, ICRU lung tissue with 0.296 g/cm3), local density rescaling (kSTL and kLTL, respectively, for soft tissue and lung tissue), or global rescaling for a lung mean density of 0.221 g/cm3 (kLT221). Significant underestimations in the mean absorbed dose (AD) were observed, with relative differences with respect to the reference (MC) of −64% for MIRD, −93% for kST, −56% for kSTL, −76% for kLT, −68% for kLT221, and −60% for kLTL. Given the high heterogeneity of lung tissue, standard dosimetric approaches cannot accurately estimate the AD. Additionally, MC results for 166Ho showed notable spatial absorbed dose inhomogeneity, highlighting the need for tailored lung dosimetry in Ho-TARE accounting for the patient-specific lung density distribution. MC-based dosimetry thus proves to be essential for safe and effective radioembolization treatment planning in the presence of LS.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Advanced Radiotherapy Techniques · Medical Imaging Techniques and Applications · Advanced X-ray and CT Imaging
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Postgraduate School of Medical Physics, Azienda Ospedaliero-Universitaria Policlinico Umberto I, 00161 Rome, Italy
Department of Medical Physics, Azienda Ospedaliero-Universitaria Policlinico Umberto I, 00161 Rome, Italy
Department of Research, Diagnosis and Innovative Technologies, Medical Physics Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy
Department of Physics and Astronomy, Università di Bologna, 40126 Bologna, Italy
Medical Physics Unit, European Institute of Oncology, IRCCS, 20141 Milan, Italy
Department of Basic and Applied Science for Engineering, University of Roma “Sapienza”, 00161 Rome, Italy
Sezione di Roma I, Istituto Nazionale di Fisica Nucleare, 00161 Rome, Italy
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