Phytochemical and Metabolomic Investigation of a Popular Traditional Plant from La Réunion: Psiloxylon mauritianum
Source abstract
Abstract
A molecular network investigation of Psiloxylon mauritianum leaf extracts from five different specimens led to the detection of a diversity of flavonoids, triterpenes, and phloroglucinols. Some compounds from these molecular classes are reported to target fever-linked symptoms (antioxidant, antiviral, anti-inflammatory, and antibacterial activities) and may explain the plant’s success as a local traditional remedy. The phytochemical study of one extract allowed the isolation and characterization of an original seco-ring-A lupane structurally similar to the anti-inflammatory betulinic acid, 11 known triterpenes, 2 flavonoids, and a chalcone. Antiviral assays highlighted the in vitro anti-Zika activity of corosolic and betulinic acids found in the plant. Some interesting structure–activity relationships could be drawn between the new compound and the known active triterpenes.
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Research context
OpenAlex topics: Natural product bioactivities and synthesis · Bioactive natural compounds · Phytochemistry and Biological Activities
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Laboratoire de Chimie et de Biotechnologie des Produits Naturels, Faculté des Sciences et Technologies, Université de La Réunion, 15 Avenue René Cassin, CS92003, CEDEX 9, 97744 Saint-Denis, France
Spectropole, FSCM, Centrale Méditerrané, CNRS, Aix-Marseille Université, Campus de Saint-Jérôme Service 511, 13397 Marseille, France
Institut de Chimie des Substances Naturelles (ICSN), CNRS UPR 2301, Université Paris Saclay, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, France
Unité Mixte Processus Infectieux en Milieu Insulaire Tropical, Université de la Réunion, INSERM U1187, CNRS UMR 9192, IRD UMR 249, Plateforme Technologique CYROI, 97490 Sainte Clotilde, France
Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Centre Médical Universitaire, Rue Michel Servet 1, 1206 Geneva, Switzerland
School of Pharmaceutical Sciences, University of Geneva, Centre Médical Universitaire, Rue Michel Servet 1, 1206 Geneva, Switzerland
Funding
European Regional Development Funds
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