Novel In Silico Strategies to Model the In Vivo Nerve Scarring Around Implanted Parylene C Devices
Source abstract
Abstract
The implantation of materials into in vivo peripheral nerves triggers the production of scar tissue. A scar capsule progressively incorporates foreign bodies, which become insulated from the surrounding environment. This phenomenon is particularly detrimental in the case of electrical active sites enveloped within scar sheets, since the loss of contact with axons highly decreases the effectiveness of neural interfaces. As a consequence, the in silico modelling of scar capsule evolution may lead to improvements in the design of intraneural structures and enhancing their reliability over time. In this work, a novel theoretical framework is proposed to model the evolution of capsule thickness over time together with an improved optimisation procedure able to avoid apparently suitable choices resulting from standard procedures. This framework provides a fast, simple, and accurate modelling of experimental data (R2=0.97), definitely improving on previous approaches.
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Research context
OpenAlex topics: Neuroscience and Neural Engineering · Conducting polymers and applications · Advanced Sensor and Energy Harvesting Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Translational Neural Engineering Area, The BioRobotics Institute, Department of Excellence in Robotics and Artificial Intelligence, Sant’Anna School of Advanced Studies, Piazza Martiri della Libertà, 33, 56127 Pisa, Italy
Institut de Neurociències, and Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas, 28029 Madrid, Spain
Secció de Fisiologia, Departament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de L’Alimentació, and Institut de Neurociències, Universitat de Barcelona, Barcelona 08028, Spain
Laboratory for Biomedical Microtechnology, Department of Microsystems Engineering (IMTEK) and BrainLinks-BrainTools Center, Albert-Ludwigs-Universität Freiburg, 79110 Freiburg im Breisgau, Germany
Translational Neural Engineering Laboratory and Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Rte Cantonale, 1015 Lausanne, Switzerland
Funding
NEXTGENERATIONEU (NGEU) · Ministry of University and Research (MUR) National Recovery and Resilience · A Multiscale integrated approach to the study of the nervous system in health and disease (DN. 1553 11.10.2022) · Tuscany Health Ecosystem (DN. 1553 11.10.2022) · HORIZON-EIC-2022-PATHFINDEROPEN, BioFunctional IntraNeural Electrodes (BioFINE) · Dr. Pier Nicola Sergi
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