Highly Photoresponsive Vertically Stacked Silicon Nanowire Photodetector with Biphasic Current Stimulator IC for Retinal Prostheses
Source abstract
Abstract
This paper presents an integrated approach for a retinal prosthesis that overcomes the scalability challenges and limitations of conventional systems that use external cameras. Silicon nanowires (SiNWs) are utilized as photonic sensors due to their nanoscale dimensions and high surface-to-volume ratio. To enhance these properties and achieve high photoresponsivity, our research team developed a vertically stacked SiNW structure using a fabrication method entirely based on dry etching. The fabricated SiNW photodetector demonstrated excellent electrical and optical characteristics, including linear I–V characteristics that confirmed ohmic contact formation and high photoresponsivity exceeding 105 A/W across the 400–800 nm wavelength range. The SiNW photodetector, following its integration with a switched capacitor stimulator circuit, exhibited a proportional increase in stimulation current in response to higher light intensity and increased SiNW density. In vitro experiments confirmed the efficacy of the integrated system in inducing neural responses from retinal cells, as indicated by an increased number of neural spikes observed at higher light intensities and SiNW densities. This study contributes to sensor technology by demonstrating an approach to integrating nanostructures and electronic components, which enhances control and functionality.
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Research context
OpenAlex topics: Neuroscience and Neural Engineering · Advanced Memory and Neural Computing · Nanowire Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Electronics and Information Convergence Engineering, Kyunghee University, Yongin 17104, Republic of Korea
Department of Biomedical Engineering, Kyunghee University, Yongin 17104, Republic of Korea
Funding
MSIT (Ministry of Science and ICT), Korea, under the ITRC (Information Technology Research Center) support program
References (35)
Show source-provided references
1. Retinitis Pigmentosa10.1016/S0140-6736(06)69740-7 ↗
2. Age-Related Macular Degeneration: Epidemiology, Genetics, Pathophysiology, Diagnosis, and Targeted Therapy10.1016/j.gendis.2021.02.009 ↗
3. Causes and prevalence of visual impairment among adults in the Unites States10.1001/archopht.122.4.477 ↗
4. Retinal Remodeling during Retinal Degeneration10.1016/j.exer.2005.03.006 ↗
5. Neural Remodeling in Retinal Degeneration10.1016/S1350-9462(03)00039-9 ↗
6. The Argus® II Retinal Prosthesis System10.1016/j.preteyeres.2015.09.003 ↗
7. Scribner, D., Johnson, L., Klein, R., Bassett, W., Howard, J., Skeath, P., Wassetman Humayun, L.B., Perkins, F., Peckerar, M., and Finch, B.J. (2003, January 24). A Retinal Prosthesis Device Based on an 80 × 40 Hybrid Microelectronic-Microwire Glass Array. Proceedings of the IEEE 2003 Custom Integrated Circuits Conference, San Jose, CA, USA.
8. Stingl, K., Schippert, R., Bartz-Schmidt, K.U., Besch, D., Cottriall, C.L., Edwards, T.L., Gekeler, F., Greppmaier, U., Kiel, K., and Koitschev, A. (2017). Interim Results of a Multicenter Trial with the New Electronic Subretinal Implant Alpha AMS in 15 Patients Blind from Inherited Retinal Degenerations. Front. Neurosci., 11.10.3389/fnins.2017.00445 ↗
9. CMOS 256-Pixel/480-Pixel Photovoltaic-Powered Subretinal Prosthetic Chips with Wide Image Dynamic Range and Bi/Four-Directional Sharing Electrodes and Their Ex Vivo Experimental Validations with Mice10.1109/TCSI.2020.2976716 ↗
10. Retinal Prosthesis Using Thin-Film Devices on a Transparent Substrate and Wireless Power Transfer10.1109/TED.2019.2960295 ↗
11. 1225-Channel Neuromorphic Retinal-Prosthesis SoC with Localized Temperature-Regulation10.1109/TBCAS.2020.3036091 ↗
12. Muqit, M.M.K., Hubschman, J.P., Picaud, S., McCreery, D.B., Van Meurs, J.C., Hornig, R., Buc, G., Deterre, M., Nouvel-Jaillard, C., and Bouillet, E. (2020). PRIMA Subretinal Wireless Photovoltaic Microchip Implantation in Non-Human Primate and Feline Models. PLoS ONE, 15.10.1371/journal.pone.0230713 ↗
13. Functionality and Performance of the Subretinal Implant Chip Alpha AMS
14. Simulation of a Phosphene-Based Visual Field: Visual Acuity in a Pixelized Vision System10.1007/BF02368135 ↗
15. Tong, W., Meffin, H., Garrett, D.J., and Ibbotson, M.R. (2020). Stimulation Strategies for Improving the Resolution of Retinal Prostheses. Front. Neurosci., 14.10.3389/fnins.2020.00262 ↗
16. Fabrication and evaluation of silicon nanowire photodetectors on flexible substrate for retinal prosthetic system
17. Low Cost Synthesis of Silicon Nanowires for Photonic Applications10.1007/s10854-019-00672-y ↗
18. Kochylas, I., Dimitriou, A., Apostolaki, M.A., Skoulikidou, M.C., Likodimos, V., Gardelis, S., and Papanikolaou, N. (2023). Enhanced Photoluminescence of R6G Dyes from Metal Decorated Silicon Nanowires Fabricated through Metal Assisted Chemical Etching. Materials, 16.10.3390/ma16041386 ↗
19. Nanowire Photodetectors10.1166/jnn.2010.2157 ↗
20. Ultrahigh Responsivity Visible and Infrared Detection Using Silicon Nanowire Phototransistors10.1021/nl1006432 ↗
21. Wafer-Level and Highly Controllable Fabricated Silicon Nanowire Transistor Arrays on (111) Silicon-on-Insulator (SOI) Wafers for Highly Sensitive Detection in Liquid and Gaseous Environments10.1007/s12274-017-1768-z ↗
22. Tintelott, M., Pachauri, V., Ingebrandt, S., and Vu, X.T. (2021). Process Variability in Top-down Fabrication of Silicon Nanowire-based Biosensor Arrays. Sensors, 21.10.3390/s21155153 ↗
23. Top-down Fabricated Silicon Nanowire Sensors for Real-Time Chemical Detection10.1088/0957-4484/21/1/015501 ↗
24. Kim, K., Lee, J.K., Han, S.J., and Lee, S. (2020). A Novel Top-down Fabrication Process for Vertically-Stacked Silicon-Nanowire Array. Appl. Sci., 10.10.3390/app10031146 ↗
25. A 3-D-Silicon Nanowire FET Biosensor Based on a Novel Hybrid Process10.1109/JMEMS.2017.2788900 ↗
26. Zhang, A. (2010). SiNW Phototransistor: Designing, Fabricating and Characterizing a High Responsibility, Broadband Photodetector. [Ph.D. Thesis, University of California].
27. Kim, C., Han, S., Kim, T., and Lee, S. (2024). Implantable pH Sensing System Using Vertically Stacked Silicon Nanowire Arrays and Body Channel Communication for Gastroesophageal Reflux Monitoring. Sensors, 24.10.3390/s24030861 ↗
28. Nam, K., Choi, G., Kim, H., Yoo, M., and Ko, H. (2021). A Potentiostat Readout Circuit with a Low-Noise and Mismatch-Tolerant Current Mirror Using Chopper Stabilization and Dynamic Element Matching for Electrochemical Sensors. Appl. Sci., 11.10.3390/app11188287 ↗
29. A CMOS Retinal Neurostimulator Capable of Focussed, Simultaneous Stimulation10.1088/1741-2560/6/3/035006 ↗
30. Implantable Nanostructured MEA with Biphasic Current Stimulator for Retinal Prostheses10.3233/THC-235001 ↗
31. Single Si Nanowire (Diameter ≤ 100 Nm) Based Polarization Sensitive near-Infrared Photodetector with Ultra-High Responsivity10.1039/C4NR03170A ↗
32. ZnO Nanowire UV Photodetectors with High Internal Gain10.1021/nl070111x ↗
33. Electrical Stimulation of Mammalian Retinal Ganglion Cells with Multielectrode Arrays10.1152/jn.01168.2005 ↗
34. Selectivity of Direct and Network-Mediated Stimulation of the Retinal Ganglion Cells with Epi-, Sub- and Intraretinal Electrodes10.1088/1741-2560/11/2/026008 ↗
35. Lee, S., Jung, S.W., Park, S., Ahn, J., Hong, S.J., Yoo, H.J., Lee, M.H., and Cho, D.I. Ultra-high responsivity, silicon nanowire photodetectors for retinal prosthesis. Proceedings of the 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems (MEMS), Paris, France, 29 January–2 February 2012.10.1109/MEMSYS.2012.6170420 ↗