The Implementation of AFM-Based Nanoscale Diagnostic Methods in the Investigation of the Degradation Process of Bacteriostatic Acrylic Film with Silver Nanoparticles
Source abstract
Abstract
In this paper, a custom-tailored investigation protocol aimed at the tests of the resistance of bacteriostatic acrylic-based film containing silver nanoparticles is presented. As hospital appliance applications were considered, it was necessary to provide a unique approach, enabling specific media exposure and utilizing high-sensitivity measurement methods to observe fine indications of material wear. Due to the presence of nanoparticles in the tested film, nanometer-resolution surface imaging is necessary. Therefore, the main source of information about its degradation process is atomic force microscopy (AFM) measurements. This particular tool is an appreciated source of information, providing quantitative data about both morphological and mechanical changes in the properties of the surface. Using such an approach, supported by standard diagnostic methods, such as colorimetry and wettability angle determination, it was possible to enable insights into the way the bacteriostatic film deteriorates and evaluate its usefulness in medical appliance applications. Further tests of various films developed by companies can be performed using the described protocol to determine the lifetime of certain products. This paper reveals the company’s practical utilization of both standardized and novel test techniques in the evaluation of new products.
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Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Nanometrology, Faculty of Electronics, Photonics and Microsystems, Wrocław University of Science and Technology, 11/17 Janiszewskiego St., 50-372 Wroclaw, Poland
Kendromed, Sołtysowicka 25 A, 51-168 Wrocław, Poland
Funding
Polish Agency for Enterprise Development within funding program EFRR/RPO WD 2014-2020
References (36)
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