Effects of Dry Granulation Operating Parameters on Forming Quality

To address the issues of the existing dry granulation process, which mostly relies on manual adjustments based on empirical experience and lacks the analysis of theoretical data, a simplified model of tablet pressing based on a modified Drucker–Prager Cap (DPC) material constitutive model was proposed to simulate and analyze the forming process of tablets, and study the impacts of the feeding speed, roller speed, friction coefficient and roller clearance on the density distribution of the pressed tablets via ABAQUS. The results show that the roller speed significantly impacts the density of tablets, and a lower roller speed and a higher friction coefficient are beneficial to the formation of tablets. As the roller clearance decreases, the average density at the clearance increases, and the unevenness of the lateral density distribution of the tablets increases, showing a distribution trend of larger density at the center and smaller density on both sides.