DataVXApplied SciencesPaper
journal article·2023-08-09Open access

Development of Inclined Applicators for Flattened Beam Intraoperative Radiotherapy

Jeong Heon Kim, Sohyun Ahn, Kwangwoo Park, Rena Lee, Jin Sung Kim

Applied Sciences· Volume 13· Issue 16
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Source abstract

Abstract

A 3D-printed applicator for intraoperative radiation therapy (IORT) using the INTRABEAM system has been introduced, designed to protect normal tissue, expand indications, and assess its effectiveness in various intraoperative settings. The study involved designing and creating inclined applicators at 0° and 45° angles, which were capable of producing flattened and unflattened beams and shielding non-target areas from radiation. The applicator was evaluated based on dose uniformity, percentage depth dose, leakage, and dose rate. The findings showed that the applicator provided a uniform beam at various depths (1.23 to 1.30 for the flattened beam and 1.25 to 1.32 for the unflattened beam) and effectively shielded against leakage, with no leakage dose measured at 1 mm from the surface. Additionally, the dose rates after 3 min of irradiation for flattened and unflattened beams were 51.0 and 52.9 cGy for 0° and 48.5 and 54.8 cGy for 45° applicators, respectively. This suggests that the applicator can efficiently deliver IORT while minimizing exposure to normal tissues, particularly in treating chest and abdominal lesions near or on critical organs. The applicator has undergone dose calibration and has moved forward to clinical application.
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Research context

OpenAlex topics: Advanced Radiotherapy Techniques · Radiation Therapy and Dosimetry · Radiation Dose and Imaging

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea

Medical Physics and Biomedical Engineering Lab (MPBEL), Yonsei University College of Medicine, Seoul 03722, Republic of Korea

Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea

Ewha Medical Research Institute, School of Medicine, Ewha Womans University, Seoul 03760, Republic of Korea

Department of Radiation Oncology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin 16995, Republic of Korea

Department of Biomedical Engineering, School of Medicine, Ewha Womans University, Seoul 03760, Republic of Korea

Funding

Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education · faculty research grant of Yonsei University College of Medicine · National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) · National Research Foundation of Korea (NRF) grant funded by the Korean government (MISIT) · Korea Institute of Energy Technology Evaluation and Planning (KETEP) grant funded by the Korean government (MOTIE)

References (27)

Show source-provided references
1. Present state and issues in IORT Physics10.1186/s13014-016-0754-z ↗
2. Intraoperative radiotherapy: Review of techniques and results10.3332/ecancer.2017.750 ↗
3. Intraoperative Radiotherapy with INTRABEAM: Technical and Dosimetric Considerations10.3389/fonc.2018.00074 ↗
4. Accelerated partial breast irradiation: Advances and controversies10.1186/s40880-016-0095-1 ↗
5. Outcomes of intraoperative radiotherapy for early-stage breast cancer: Experience from a multidisciplinary breast oncology program10.1016/j.amjsurg.2019.06.014 ↗
6. Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial10.1136/bmj.m2836 ↗
7. Comparison of IORT (Radical and Boost Dose) and EBRT in Terms of Disease-Free Survival and Overall Survival according to Demographic, Pathologic, and Biological Factors in Patients with Breast Cancer
8. Optimal Timing of Radiotherapy after Incomplete Transarterial Chemoembolization for Barcelona Clinic Liver Cancer Stage B Hepatocellular Carcinoma10.3349/ymj.2021.62.5.409 ↗
9. Role of intraoperative radiotherapy in the treatment of sacral chordoma10.1016/j.spinee.2017.08.255 ↗
10. Intraoperative radiotherapy as an immediate adjuvant treatment of rectal cancer due to limited access to external-beam radiotherapy10.1186/s13014-020-1458-y ↗
11. Intraoperative Electron Beam Radiotherapy (IOERT) in the management of locally advanced or recurrent cervical cancer10.1186/1748-717X-8-80 ↗
12. Intraoperative radiotherapy (IORT) in the treatment of head and neck cancer
13. Intraoperative radiation therapy for locally advanced and recurrent head and neck cancer10.1200/JCO.2022.40.16_suppl.6058 ↗
14. Intraoperative Radiotherapy for Resectable Pancreatic Cancer Using a Low-Energy X-ray Source: Postoperative Complications and Early Outcomes10.3349/ymj.2022.63.5.405 ↗
15. Roeder, F., Goetz, J.-M., Habl, G., Bischof, M., Krempien, R., Buechler, M.W., Hensley, F.W., Huber, P.E., Weitz, J., and Debus, J. (2012). Intraoperative Electron Radiation Therapy (IOERT) in the management of locally recurrent rectal cancer. BMC Cancer, 12.10.1186/1471-2407-12-592 ↗
16. Intraoperative radiation therapy (IORT) in pancreatic cancer10.1186/s13014-016-0753-0 ↗
17. High dose-rate Intra-Operative Radiation Therapy During High Risk Genitourinary Surgery: Initial Observations and a Proposal for its Study in Bladder Cancer10.3233/BLC-170104 ↗
18. The actual benefit of intraoperative radiation therapy using 50 kV x-rays in early breast cancer: A retrospective study of 676 patients10.1111/tbj.13827 ↗
19. Intraoperative radiotherapy (IORT) for breast cancer using the Intrabeam system10.1177/030089160509100411 ↗
20. A protocol for EBT3 radiochromic film dosimetry using reflection scanning10.1118/1.4901308 ↗
21. Evaluation of the uncertainty in an EBT3 film dosimetry system utilizing net optical density10.1120/jacmp.v17i5.6262 ↗
22. A novel approach for superficial intraoperative radiotherapy (IORT) using a 50 kV X-ray source: A technical and case report10.1120/jacmp.v15i1.4502 ↗
23. Quality Assurance of a 50-kV Radiotherapy Unit Using EBT3 GafChromic Film: A Feasibility Study10.1177/1533034614565910 ↗
24. Assessment of clinically relevant dose distributions in pelvic IOERT using Gafchromic EBT3 films10.1016/j.ejmp.2015.05.013 ↗
25. Dosimetric characteristics of INTRABEAM® flat and surface applicators
26. Intraoperative Electron Radiotherapy (IOERT) in the Treatment of Primary Breast Cancer10.1159/000489637 ↗
27. Intraoperative radiotherapy in breast conserving surgery: IORT in Breast Conserving Surgery10.1002/jso.23620 ↗