Tumor-Induced Osteomalacia as a Result of a Phosphaturic Mesenchymal Tumor: Detecting Rare Origin
Source abstract
Abstract
Phosphaturic mesenchymal tumor (PMT) is strongly related to tumor-induced osteomalacia (TIO) which brings diverse skeletal events, such as bony deformities, gait disturbance, and multiple bone fractures. Overexpressed fibroblast growth factor 23 by the tumor induces hypophosphatemia leading to the oncogenic osteomalacia, a rare paraneoplastic syndrome. PMT occurring in the oral and maxillofacial regions is extremely rare, and this case highlights the need to understand mechanisms by which local lesions can affect systemic conditions, and the importance of a combination of physical examinations, laboratory investigations, and radiologic investigations for a decisive diagnosis.
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Research context
OpenAlex topics: Parathyroid Disorders and Treatments · Bone health and treatments · Medical Imaging and Pathology Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyung Hee University, Seoul 02447, Republic of Korea
Department of Dentistry, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea
Department of Pathology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea
References (36)
Show source-provided references
1. Phosphaturic mesenchymal tumors: A review and update10.1053/j.semdp.2019.07.002 ↗
2. Tumor-induced osteomalacia10.1530/ERC-11-0006 ↗
3. Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity—An analysis of 32 cases and a comprehensive review of the literature10.1097/00000478-200401000-00001 ↗
4. Tumor induced osteomalacia in head and neck region: Single center experience and systematic review10.1530/EC-19-0341 ↗
5. Tumor-induced osteomalacia
6. Four cases of acquired hypophosphataemic (‘oncogenic’) osteomalacia. Problems of diagnosis, treatment and long-term management10.1093/rheumatology/39.12.1415 ↗
7. Salivary gland pleomorphic adenoma10.1097/COC.0b013e3181595ae0 ↗
8. Salivary gland tumours in a Mexican sample. A retrospective study
9. Histopathology of pleomorphic adenoma in the parotid gland: A prospective unselected series of 100 cases10.1097/00005537-200112000-00024 ↗
10. Central giant cell granuloma of the jaws: A clinical, radiologic, and histopathologic study of 26 cases10.1016/j.tripleo.2005.02.060 ↗
11. Central giant cell granuloma of the jaw: A review of the literature with emphasis on therapy options10.1016/j.tripleo.2007.04.003 ↗
12. Dental aspects of hyperparathyroidism10.1016/0030-4220(68)90249-1 ↗
13. Maxillary brown tumor caused by secondary hyperparathyroidism in a boy
14. Brown tumor of the mandible10.1016/S0196-0709(96)90075-7 ↗
15. Phosphaturic mesenchymal tumors. A polymorphous group causing osteomalacia or rickets10.1002/1097-0142(19870415)59:8<1442::AID-CNCR2820590810>3.0.CO;2-Q ↗
16. Tumor-induced osteomalacia10.1023/A:1010006811394 ↗
17. Tumor-induced osteomalacia: Clinical and basic studies10.1359/jbmr.1997.12.9.1502 ↗
18. Phosphaturic mesenchymal tumor-induced rickets10.1007/s100240050008 ↗
19. Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia10.1073/pnas.101545198 ↗
20. Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia10.1056/NEJMoa020881 ↗
21. FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis10.1359/JBMR.0301264 ↗
22. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF2310.1038/81664 ↗
23. Tumor-induced osteomalacia10.1001/jama.294.10.1260 ↗
24. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism10.1038/ng1905 ↗
25. Audran, M., and Kumar, R. (1985, January 1). The physiology and pathophysiology of vitamin D. Proceedings of the Mayo Clinic Proceedings, Olmsted County, MN, USA.10.1016/S0025-6196(12)64791-0 ↗
26. The pathophysiology and clinical characteristics of severe hypophosphatemia10.1001/archinte.1977.03630140051013 ↗
27. Fanconi syndrome in adults: A manifestation of a latent form of myeloma10.1016/0002-9343(75)90601-4 ↗
28. Disorders of phosphate homeostasis10.1002/9780470623992.ch69 ↗
29. Determination of the elimination half-life of fibroblast growth factor-2310.1210/jc.2006-2865 ↗
30. Venous sampling for fibroblast growth factor-23 confirms preoperative diagnosis of tumor-induced osteomalacia10.1210/jc.2004-0406 ↗
31. Tumor-induced osteomalacia: A case of diagnostic dilemma10.1097/RLU.0b013e3180a1ad1d ↗
32. PET/CT localization of phosphaturic mesenchymal neoplasm causing tumor-induced osteomalacia10.1097/01.rlu.0000257180.03964.51 ↗
33. Oncogenic osteomalacia: Diagnostic importance of fibroblast growth factor 23 and F-18 fluorodeoxyglucose PET/CT scan for the diagnosis and follow-up in one case10.1016/j.bone.2005.01.001 ↗
34. Oncogenic osteomalacia associated with mesenchymal tumour detected by indium-111 octreotide scintigraphy10.1046/j.1365-2265.2001.01056.x ↗
35. Selective venous catheterization for the localization of phosphaturic mesenchymal tumors10.1002/jbmr.316 ↗
36. Tumor-induced osteomalacia10.1016/S0049-0172(95)80016-6 ↗