Biosynthesis of (±)-Differolide, an Antioxidant Isolate from Streptomyces qaidamensis S10T
Source abstract
Abstract
Streptomyces from unexplored or underexplored environments may be an essential source of discoveries of bioactive molecules. One such example is Streptomyces qaidamensis S10T, which was isolated from a sand sample collected in Qaidam Basin, Qinghai Province, China. Here, we report on (±)-differolide, an antioxidant isolated from S. qaidamensis, and verified with scavenging experiments on 2,2-diphenyl-1-picrylhydrazyl (DPPH). The biosynthetic gene cluster responsible for synthesizing the compound was also identified using comparative genomic methods. These results provide a basis for further study of the biological activities of (±)-differolide, which also make it possible to develop as an antioxidant medicine.
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Research context
OpenAlex topics: Microbial Natural Products and Biosynthesis · Natural product bioactivities and synthesis · Carbohydrate Chemistry and Synthesis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Cryospheric Science, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China
Key Laboratory of Extreme Environmental Microbial Resources and Engineering, Lanzhou 730000, China
University of Chinese Academy of Sciences, Beijing 100049, China
Key Laboratory of Desert and Desertification, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China
Agronomy College, Gansu Agricultural University, Lanzhou 730000, China
Funding
National Key R&D Program of China · National Natural Science Foundation of China · The Scientific Project of Gansu Province, China
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