Three-Dimensional Characterization of Peripapillary Retinal Pigment Epithelium-Basement Membrane Layer in Patients following Lumbar Puncture
Source abstract
Abstract
Purpose: To develop and test an innovative semi-automatic method for quantifying the three-dimensional morphology of the peripapillary retinal pigment epithelium-basement membrane (ppRPE/BM) layer, with application to lumbar puncture (LP) patients. Methods: Nineteen patients undergoing LP were recruited. The optic nerve head images of both eyes were acquired in 12 radial directions using optical coherence tomography (OCT) before and after LP. For each OCT image, the ppRPE/BM layer was automatically segmented with manual corrections by independent graders when necessary. The linear regression model of the ppRPE/BM layer was fitted using the least squares approach, and the ppRPE/BM layer angle was measured as the slope of the linear regression line. The Bland–Altman plots and intraclass correlations (ICC) were used to assess the inter-observer reliabilities in measuring the ppRPE/BM layer angle. The repeated measures ANOVA analysis was applied to determine whether the ppRPE/BM layer angle changes following LP varied across the radial directions. Results: The percentages of scans that required manual corrections were 24% and 32% in the right eyes and left eyes, respectively. The Bland–Altman plots and ICC demonstrated excellent inter-observer reliability. The ppRPE/BM layer angle varied significantly across the 12 radial OCT scanning directions both before and after LP. However, the LP-induced changes in the ppRPE/BM layer angle across different radial directions were not statistically significant (p-value > 0.01). Conclusions: The three-dimensional quantifications of the ppRPE/BM layer angles, enabled by the semi-automatic method, provided enhanced information of the optic nerve head structure. For LP patients, the ppRPE/BM layer angle changes following the LP did not vary significantly across various radial directions, indicating that it could be evaluated in any radial direction.
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Research context
OpenAlex topics: Glaucoma and retinal disorders · Retinal and Macular Surgery · Intraocular Surgery and Lenses
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588-0656, USA
Department of Biomedical and Chemical Engineering, Florida Institute of Technology, Melbourne, FL32901, USA
Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198-8440, USA
Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE 68105-1119, USA
References (25)
Show source-provided references
1. Optic disc edema in raised intracranial pressure. III. A pathologic study of experimental papilledema10.1001/archopht.1977.04450080158022 ↗
2. Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: A case-control study10.1167/iovs.08-2228 ↗
3. Invasive and noninvasive means of measuring intracranial pressure: A review10.1088/1361-6579/aa7256 ↗
4. Ultrahigh-resolution ophthalmic optical coherence tomography10.1038/86589 ↗
5. Spectral Domain Optical Coherence Tomography in Glaucoma: Qualitative and Quantitative Analysis of the Optic Nerve Head and Retinal Nerve Fiber Layer (An AOS Thesis)
6. Optical Coherence Tomography Measurements and Analysis Methods in Optical Coherence Tomography Studies of Diabetic Macular Edema10.1016/j.ophtha.2007.12.004 ↗
7. Enhanced Depth Imaging Detects Lamina Cribrosa Thickness Differences in Normal Tension Glaucoma and Primary Open-Angle Glaucoma10.1016/j.ophtha.2011.07.033 ↗
8. Recent advances in OCT imaging of the lamina cribrosa10.1136/bjophthalmol-2013-304751 ↗
9. Quantitative association between peripapillary Bruch’s membrane shape and intracranial pressure10.1167/iovs.17-21592 ↗
10. Effects of Lowering Cerebrospinal Fluid Pressure on the Shape of the Peripapillary Retina in Intracranial Hypertension10.1167/iovs.14-15298 ↗
11. Shape analysis of the peripapillary RPE layer in papilledema and ischemic optic neuropathy10.1167/iovs.11-7918 ↗
12. Eigenregions for image classification10.1109/TPAMI.2004.123 ↗
13. Principal Component analysis: A review and recent developments10.1098/rsta.2015.0202 ↗
14. Optical coherence tomography of the swollen optic nerve head: Deformation of the peripapillary retinal pigment epithelium layer in papilledema10.1167/iovs.10-6782 ↗
15. Association Between Peripapillary Bruch’s Membrane Shape and Intracranial Pressure: Effect of Image Acquisition Pattern and Image Analysis Method10.3389/fneur.2018.01137 ↗
16. Optical Coherence Tomography Analysis of the Optic Nerve Head and Surrounding Structures in Long-Duration International Space Station Astronauts10.1001/jamaophthalmol.2017.6226 ↗
17. Retinal Nerve Fiber Layer Segmentation on FD-OCT Scans of Normal Subjects and Glaucoma Patients10.1364/BOE.1.001358 ↗
18. Ratiometric analysis of optical coherence tomography–measured in vivo retinal layer thicknesses for the detection of early diabetic retinopathy10.1002/jbio.201600282 ↗
19. Girish, G.N., Kothari, A.R., and Rajan, J. (2017). Marker controlled watershed transform for intra-retinal cysts segmentation from optical coherence tomography b-scans. Pattern Recognit. Lett., 100.10.1016/j.patrec.2017.08.031 ↗
20. Nicotine accelerates diabetes-induced retinal changes10.3109/02713683.2014.924147 ↗
21. Statistical methods for assessing agreement between two methods of clinical measurement10.1016/S0140-6736(86)90837-8 ↗
22. Intraclass correlations: Uses in assessing rater reliability10.1037/0033-2909.86.2.420 ↗
23. Deformation of Optic Nerve Head and Peripapillary Tissues by Horizontal Duction10.1016/j.ajo.2016.10.001 ↗
24. Progressive Deformation of the Optic Nerve Head and Peripapillary Structures by Graded Horizontal Duction
25. Optic nerve sheath diameter, intracranial pressure and acute mountain sickness on Mount Everest: A longitudinal cohort study10.1136/bjsm.2007.045286 ↗