journal article·2023-09-17Open access

Hybrid Intelligent Pattern Recognition Systems for Mass Segmentation and Classification: A Pilot Study on Full-Field Digital Mammograms

Anastasios Dounis, Andreas-Nestor Avramopoulos, Maria Kallergi

Applied Sciences· Volume 13· Issue 18

Abstract

Governments and health authorities emphasize the importance of early detection of breast cancer, usually through mammography, to improve prognosis, increase therapeutic options and achieve optimum outcomes. Despite technological advances and the advent of full-field digital mammography (FFDM), diagnosis of breast abnormalities on mammographic images remains a challenge due to qualitative variations in different tissue types and densities. Highly accurate computer-aided diagnosis (CADx) systems could assist in the differentiation between normal and abnormal tissue and the classification of abnormal tissue as benign or malignant. In this paper, classical, advanced fuzzy sets and fusion techniques for image enhancement were combined with three different thresholding methods (Global, Otsu and type-2 fuzzy sets threshold) and three different classifying techniques (K-means, FCM and ANFIS) for the classification of breast masses on FFDM. The aim of this paper is to identify the performance of the advanced fuzzy sets, fuzzy sets type-2 segmentation, decisions based on K-means and FCM, and the ANFIS classifier. Sixty-three combinations were evaluated on ninety-seven digital mammographic masses (sixty-five benign and thirty-two malignant). The performance of the sixty-three combinations was evaluated by estimating the accuracy, the F1 score, and the area under the curve (AUC). LH-XWW enhancement method with Otsu thresholding and FCM classifier outperformed all other combinations with an accuracy of 95.17%, F1 score of 89.42% and AUC of 0.91. This algorithm seems to offer a promising CADx system for breast cancer diagnosis on FFDM.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: AI in cancer detection · Brain Tumor Detection and Classification · Infrared Thermography in Medicine

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biomedical Engineering, Egaleo Park Campus, University of West Attica, 12243 Athens, Greece

References (60)

Show source-provided references
1. (2023, August 20). American Cancer Society Breast Cancer Statistics|How Common Is Breast Cancer?. Available online: https://www.cancer.org/cancer/types/breast-cancer/about/how-common-is-breast-cancer.html.
2. Hall, J. (2023, August 20). Large Mammography Study Shows Significant Benefits with AI-Aided Screening. Available online: https://www.diagnosticimaging.com/view/large-mammography-study-significant-benefits-with-ai-aided-screening?utm_source=sfmc&utm_medium=email&utm_campaign=08062023_DI_eNL_unsupported&eKey=a2FsbGVyZ2lAdGVpYXRoLmdy.
3. Dounis, A., Avramopoulos, A.-N., and Kallergi, M. (2023). Advanced Fuzzy Sets and Genetic Algorithm Optimizer for Mammographic Image Enhancement. Electronics, 12.10.3390/electronics12153269 ↗
4. Enhancement and Segmentation of Medical Images through Pythagorean Fuzzy Sets-An Innovative Approach10.1007/s00521-022-07043-5 ↗
5. A Threshold Selection Method from Gray-Level Histograms10.1109/TSMC.1979.4310076 ↗
6. Fuzzy Based Image Segmentation10.1007/978-3-540-36420-7_5 ↗
7. Chowdhary, C.L., Mittal, M.P.K., Pattanaik, P.A., and Marszalek, Z. (2020). An Efficient Segmentation and Classification System in Medical Images Using Intuitionist Possibilistic Fuzzy C-Mean Clustering and Fuzzy SVM Algorithm. Sensors, 20.10.3390/s20143903 ↗
8. Medical Image Based Breast Cancer Diagnosis: State of the Art and Future Directions10.1016/j.eswa.2020.114095 ↗
9. Color-Based Object Segmentation Method Using Artificial Neural Network10.1016/j.simpat.2016.02.011 ↗
10. Hassanat, A.B.A., Alkasassbeh, M., Al-awadi, M., and Alhasanat, E.A.A. (2015, January 7–9). Colour-Based Lips Segmentation Method Using Artificial Neural Networks. Proceedings of the 2015 6th International Conference on Information and Communication Systems (ICICS), Amman, Jordan.10.1109/IACS.2015.7103225 ↗
11. Yazdanbakhsh, O., and Dick, S. (2020). A Deep Neuro-Fuzzy Network for Image Classification. arXiv.
12. The Application of Traditional Machine Learning and Deep Learning Techniques in Mammography: A Review10.3389/fonc.2023.1213045 ↗
13. Breast Cancer Classification Using Deep Q Learning (DQL) and Gorilla Troops Optimization (GTO)10.1016/j.asoc.2023.110292 ↗
14. Automated Breast Mass Classification System Using Deep Learning and Ensemble Learning in Digital Mammogram10.1109/ACCESS.2021.3071297 ↗
15. Dual Convolutional Neural Networks for Breast Mass Segmentation and Diagnosis in Mammography10.1109/TMI.2021.3102622 ↗
16. Parah, S.A., Rashid, M., and Varadarajan, V. (2022). Artificial Intelligence for Innovative Healthcare Informatics, Springer International Publishing.10.1007/978-3-030-96569-3 ↗
17. A Novel Machine Learning Approach on Texture Analysis for Automatic Breast Microcalcification Diagnosis Classification of Mammogram Images10.1007/s00432-023-04571-y ↗
18. Development of Intelligent Systems Based on Bayesian Regularization Network and Neuro-Fuzzy Models for Mass Detection in Mammograms: A Comparative Analysis10.1016/j.cmpb.2015.10.017 ↗
19. Review of Medical Image Classification Using the Adaptive Neuro-Fuzzy Inference System10.4103/2228-7477.108171 ↗
20. Image Segmentation Using Deep Learning: A Survey
21. Going Deeper: Magnification-invariant Approach for Breast Cancer Classification Using Histopathological Images10.1049/cvi2.12021 ↗
22. LBTS-Net: A Fast and Accurate CNN Model for Brain Tumour Segmentation10.1049/htl2.12005 ↗
23. Abdel Rahman, A.S., Belhaouari, S.B., Bouzerdoum, A., Baali, H., Alam, T., and Eldaraa, A.M. (2020, January 2–5). Breast Mass Tumor Classification Using Deep Learning. Proceedings of the 2020 IEEE International Conference on Informatics, IoT, and Enabling Technologies (ICIoT), Doha, Qatar.10.1109/ICIoT48696.2020.9089535 ↗
24. Deep Learning in Mammography Images Segmentation and Classification: Automated CNN Approach10.1016/j.aej.2021.03.048 ↗
25. Nemade, V., Pathak, S., and Dubey, A.K. (2023). Deep Learning-Based Ensemble Model for Classification of Breast Cancer. Microsyst. Technol.10.1007/s00542-023-05469-y ↗
26. A Novel Quality Control Algorithm for Medical Image Segmentation Based on Fuzzy Uncertainty10.1109/TFUZZ.2022.3228332 ↗
27. Mammography Images Segmentation Based on Fuzzy Set and Thresholding
28. Intuitionistic Fuzzy Segmentation of Medical Images10.1109/TBME.2010.2041000 ↗
29. Tahoun, M., Almazroi, A.A., Alqarni, M.A., Gaber, T., Mahmoud, E.E., and Eltoukhy, M.M. (2020). A Grey Wolf-Based Method for Mammographic Mass Classification. Appl. Sci., 10.10.3390/app10238422 ↗
30. Castro-Tapia, S., Castañeda-Miranda, C.L., Olvera-Olvera, C.A., Guerrero-Osuna, H.A., Ortiz-Rodriguez, J.M., Martínez-Blanco, M.D.R., Díaz-Florez, G., Mendiola-Santibañez, J.D., and Solís-Sánchez, L.O. (2021). Classification of Breast Cancer in Mammograms with Deep Learning Adding a Fifth Class. Appl. Sci., 11.10.3390/app112311398 ↗
31. Mobark, N., Hamad, S., and Rida, S.Z. (2022). CoroNet: Deep Neural Network-Based End-to-End Training for Breast Cancer Diagnosis. Appl. Sci., 12.10.3390/app12147080 ↗
32. Alshehri, A., and AlSaeed, D. (2022). Breast Cancer Detection in Thermography Using Convolutional Neural Networks (CNNs) with Deep Attention Mechanisms. Appl. Sci., 12.10.3390/app122412922 ↗
33. Du, G., Dong, M., Sun, Y., Li, S., Mu, X., Wei, H., Ma, L., and Liu, B. (2019). A New Method for Detecting Architectural Distortion in Mammograms by NonSubsampled Contourlet Transform and Improved PCNN. Appl. Sci., 9.10.3390/app9224916 ↗
34. Mammogram Enhancement Using Intuitionistic Fuzzy Sets10.1109/TBME.2016.2624306 ↗
35. Yousefi, J. (2011). Image Binarization Using Otsu Thresholding Algorithm, University of Guelph.
36. Characteristic Analysis of Otsu Threshold and Its Applications10.1016/j.patrec.2011.01.021 ↗
37. (2023, August 08). MathWorks MATLAB for Artificial Intelligence. Available online: https://www.mathworks.com/.
38. Image Thresholding Using Type II Fuzzy Sets10.1016/j.patcog.2005.02.014 ↗
39. Image Texture Feature Extraction Using GLCM Approach
40. Brain Tumor Detection in MRI Images Using Adaptive-ANFIS Classifier with Segmentation of Tumor and Edema10.1007/s00500-022-07687-4 ↗
41. Hossain, E., and Rahaman, M.A. (2018, January 13–15). Bone Cancer Detection & Classification Using Fuzzy Clustering & Neuro Fuzzy Classifier. Proceedings of the 2018 4th International Conference on Electrical Engineering and Information & Communication Technology (iCEEiCT), Dhaka, Bangladesh.10.1109/CEEICT.2018.8628164 ↗
42. A Lower Envelope Weber Contrast Detection Algorithm for Steel Bar Surface Pit Defects10.1016/j.optlastec.2012.05.016 ↗
43. Contrast in Complex Images10.1364/JOSAA.7.002032 ↗
44. Image Enhancement and Thresholding by Optimization of Fuzzy Compactness10.1016/0167-8655(88)90122-5 ↗
45. Jähne, B., Haussecker, H., and Geissler, P. (1999). Handbook of Computer Vision and Applications, Academic Press, Inc.
46. Rezhna Hassan Faraj Data Normalization and Standardization: A Technical Report
47. Improving the Mann–Whitney Statistical Test for Feature Selection: An Approach in Breast Cancer Diagnosis on Mammography10.1016/j.artmed.2014.12.004 ↗
48. Exhaustive Search, Combinatorial Optimization and Enumeration: Exploring the Potential of Raw Computing Power
49. How Fast Is the K-Means Method?10.1007/s00453-004-1127-9 ↗
50. Arthur, D., and Vassilvitskii, S. (2006, January 5). How Slow Is the K-Means Method?. Proceedings of the twenty-second annual symposium on Computational geometry, Sedona, AZ, USA.
51. Hyperspectral Imaging and K-Means Classification for Histologic Evaluation of Ductal Carcinoma In Situ10.3389/fonc.2018.00017 ↗
52. Kharrat, A., Benamrane, N., Messaoud, M.B., and Abid, M. (2009, January 6–8). Detection of Brain Tumor in Medical Images. Proceedings of the 2009 3rd International Conference on Signals, Circuits and Systems (SCS), Medenine, Tunisia.10.1109/ICSCS.2009.5412577 ↗
53. Liu, Y., Li, W., and Li, Y. (2007, January 13–15). Network Traffic Classification Using K-Means Clustering. Proceedings of the Second International Multi-Symposiums on Computer and Computational Sciences (IMSCCS 2007), Iowa City, IA, USA.10.1109/IMSCCS.2007.52 ↗
54. Fuzzy C-Means (FCM) Clustering Algorithm: A Decade Review from 2000 to 2014
55. Comparing the Performance of Traditional Cluster Analysis, Self-Organizing Maps and Fuzzy C-Means Method for Strategic Grouping10.1016/j.eswa.2009.04.022 ↗
56. A Modified Intuitionistic Fuzzy Clustering Algorithm for Medical Image Segmentation
57. Attentive Hierarchical ANFIS with Interpretability for Cancer Diagnostic10.1016/j.eswa.2022.117099 ↗
58. Development of an Adaptive Neuro-Fuzzy Classifier Using Linguistic Hedges: Part 110.1016/j.eswa.2010.02.108 ↗
59. Measures of Diagnostic Accuracy: Sensitivity, Specificity, PPV and NPV10.1177/201010581102000411 ↗
60. (2023, August 20). Effective Health Care Program, Agency for Healthcare Research and Quality Systematic Review: Core Needle and Open Surgical Biopsy for Diagnosis of Breast Lesions: An Update to the 2009 Report, Available online: https://effectivehealthcare.ahrq.gov/products/breast-biopsy-update/research.