RNA Modification Related Diseases and Sensing Methods
Source abstract
Abstract
Epitranscriptomics is the study of RNA base modifications, including functionally relevant transcriptomic changes. Epitranscriptomics has been actively studied in recent years and has been reported to play important roles in development, homeostasis, the immune system, and various life phenomena such as cancer, neurological diseases, and infectious diseases. However, a major problem is the development of sequencing methods to map RNA base modifications throughout the transcriptome. In recent years, various methods for RNA base modification have been actively studied, and we are beginning to successfully measure base modifications that have been difficult to measure in previous years. In this review, we will discuss in detail the biological significance of RNA modifications and the latest techniques for detecting RNA modifications.
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Research context
OpenAlex topics: RNA modifications and cancer · Cancer-related molecular mechanisms research · RNA and protein synthesis mechanisms
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Biological Data Science Research Group, Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Science and Technology (AIST), Koto 135-0064, Tokyo, Japan
Division of Cancer Biology, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda 278-0022, Chiba, Japan
Division of Medical Data Science, Research Institute for Science and Technology (RIST), Tokyo University of Science, Noda 278-0022, Chiba, Japan
Funding
Grant-in-Aid for the Japan Society for the Promotion of Science (JSPS) · Princess Takamatsu Cancer Research Fund · Project Mirai Cancer Research
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