Scale-up and Economic Assessment of Biofunctional Particles Synthesis for Bilirubin Removal
Source abstract
Abstract
The scale-up and the economic feasibility of the synthesis of St-MMA-GMA-PEGMA particles biofunctionalized with HSA were studied. First, the geometrical similarity of laboratory and pilot plant reactors was checked to develop the scale up of the process according to a criterion of partial similarity. The selected criterion was constant Re number. Then, a reaction in the pilot plant scale was carried out, confirming the suitability of the scale-up criterion, since particles with similar characteristics (same particle size with a deviation of just 6%) and functional groups were obtained. Finally, the design of an industrial plant able to produce 581 Tm/year of HSA functionalized St-MMA-GMA-PEGMA particles was addressed. The economic feasibility of this plant was confirmed by a value of internal rate of return (IRR) of 14.8% and a net present value (NPV) of 5452 M€, with a payback time between six and seven years, for the price of a cartridge 25% lower than that from the current treatments for bilirubin removal from patients with liver failure.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Enzyme Catalysis and Immobilization · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemical Engineering, Institute of Chemical and Environmental Technology, University of Castilla-La Mancha, Avda. De Camilo José Cela 12, 13071 Ciudad Real, Spain
Department of Anesthesiology and Critical Care Medicine, University General Hospital, Obispo Rafael Torija s/n, 13005 Ciudad Real, Spain
Faculty of Medicine, University of Castilla-La Mancha, Camino de Moledores, s/n, 13071 Ciudad Real, Spain
Translational Research Unit, University General Hospital and Research Institute of Castilla-La Mancha (IDISCAM), 13071 Ciudad Real, Spain
Funding
Spanish Ministry of Science, Innovation and Universities · regional Government of Castilla-La Mancha
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