Comprehensive Assessment of Left Intraventricular Hemodynamics Using a Finite Element Method: An Application to Dilated Cardiomyopathy Patients
Source abstract
Abstract
In this paper, we applied a method for quantifying several left intraventricular hemodynamic parameters from 4D Flow data and its application in a proof-of-concept study in dilated cardiomyopathy (DCM) patients. In total, 12 healthy volunteers and 13 DCM patients under treatment underwent short-axis cine b-SSFP and 4D Flow MRI. Following 3D segmentation of the left ventricular (LV) cavity and registration of both sequences, several hemodynamic parameters were calculated at peak systole, e-wave, and end-diastole using a finite element approach. Sensitivity, inter- and intra-observer reproducibility of hemodynamic parameters were evaluated by analyzing LV segmentation. A local analysis was performed by dividing the LV cavity into 16 regions. We found significant differences between volunteers and patients in velocity, vorticity, viscous dissipation, energy loss, and kinetic energy at peak systole and e-wave. Furthermore, although five patients showed a recovered ejection fraction after treatment, their hemodynamic parameters remained low. We obtained several hemodynamic parameters with high inter- and intra-observer reproducibility. The sensitivity study revealed that hemodynamic parameters showed a higher accuracy when the segmentation underestimates the LV volumes. Our approach was able to identify abnormal flow patterns in DCM patients compared to volunteers and can be applied to any other cardiovascular diseases.
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Research context
OpenAlex topics: Cardiovascular Function and Risk Factors · Cardiomyopathy and Myosin Studies · Cardiac Valve Diseases and Treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Biomedical Imaging Center, School of Engineering, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile
Electrical Engineering Department, School of Engineering, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile
Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago 7820436, Chile
School of Biomedical Engineering, Universidad de Valparaíso, Valparaíso 2362905, Chile
Radiology Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 833023, Chile
Guy’s and St Thomas’ NHS Foundation Trust, London SE1 7EH, UK
School of Imaging Sciences and Biomedical Engineering, Faculty of Science of Life and Medicine, King’s College London, London WC2R 2LS, UK
Division of Biomedical Engineering and Imaging Sciences, Department of Biomedical Engineering, King’s College London, London WC2R 2LS, UK
Department of Biomedical Engineering and Cardiac Surgery, University of Michigan, North Campus Research Center, Ann Arbor, MI 48109, USA
Department of Mechanical Engineering, Universidad Técnica Federico Santa María, Valparaíso 2390123, Chile
Structural and Geotechnical Engineering Department, School of Engineering, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile
Institute for Biological and Medical Engineering, School of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile
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