Dietary Soy Impact on Host Transcriptome Profile—A Review
Source abstract
Abstract
Whether eaten, drank, or taken in the form of supplements, soybean has been a part of the human diet for centuries. The dietary use of soybean has been extensively proven to be beneficial for human health, protecting against a wide range of chronic diseases. However, our knowledge regarding the impact of soy intake on global gene expression is still incomplete. The present review summarizes and compares data describing the transcriptional changes in several tissues from two different phyla (fish and mammals) upon soybean diet supplementation. We performed comparative STRING-based pathway enrichment analysis of both individual and aggregated soy-induced transcriptome data in fish and mammals and identified the signaling pathways common between the two datasets. We hypothesize that these pathways represent a conserved transcriptome response to the soy-enriched dietary challenge.
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Research context
OpenAlex topics: Phytoestrogen effects and research · Nutrition, Genetics, and Disease · Genetic Mapping and Diversity in Plants and Animals
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Biochemistry Department, University of Medicine and Pharmacy “Victor Babes”, 300041 Timisoara, Romania
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