Mesenchymal Stem Cell Applications in Spine Disorders: A Comprehensive Review
Source abstract
Abstract
Mesenchymal stem cells (MSCs) are increasingly being employed in a number of orthopedic settings, in particular in the treatment of hip and knee osteoarthritis. Recently, the use MSCs has been investigated for different spine settings. However, the use of these cells is not yet widespread in the clinical practice. The aim of this review was to investigate the current literature regarding the use of MSCs in different spine conditions and discuss possible future applications. In particular, degenerative disc disease is the most studied field for MSC application, and is the only one that has already reached the clinical practice, albeit not routinely. Spinal cord injuries are another extensively investigated use of MSCs: despite encouraging preliminary results, a consensus on the efficacy of stem cell therapy for spinal cord injuries has not yet been reached, and their use is still only experimental.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Mesenchymal stem cell research · Biomedical Ethics and Regulation · Spine and Intervertebral Disc Pathology
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Orthopaedics, Trauma and Reconstructive Surgery, RWTH Aachen University, 52074 Aachen, Germany
Department of Spine Surgery, Eifelklinik St. Brigida, 52152 Simmerath, Germany
Department of Orthopaedic and Trauma Surgery, St-Josef-Krankenhaus, 52441 Linnich, Germany
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