journal article·2021-07-08Open access

Thermal Physics and Glaucoma II: Preliminary Evidences for a Thermophysical Design of a Possible Visible-Light-Photons Therapy

Giulia Grisolia, Mariarosa Astori, Antonio Ponzetto, Antonio Vercesi, Umberto Lucia

Applied Sciences· Volume 11· Issue 14

Abstract

Recently, a non-equilibrium thermodynamic approach has been developed in order to model the fundamental role of the membrane electric potential in the cell behaviour. A related new viewpoint is introduced, with a design of a photobiomodulation treatment in order to restore part of the visual field. Here, a first step in experimental evidence of the validity of the thermodynamic approach is developed. This result represents the starting point for future experimental improvements for light stimulation in order to improve the quality of life of the patients. The future possible therapy will be in addition to the pharmacological treatments.
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Research context

OpenAlex topics: Photoreceptor and optogenetics research · Retinal Development and Disorders · Neuroscience and Neural Engineering

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Dipartimento Energia “Galileo Ferraris”, Politecnico di Torino, Corso Duca Degli Abruzzi 24, 10129 Torino, Italy

Dipartimento di Oculistica, Azienda Ospedaliera Nazionale “SS. Antonio e Biagio e Cesare Arrigo”, Via Venezia 7, 15121 Alessandria, Italy

Department of Medical Sciences, University of Torino, Corso A.M. Dogliotti 14, 10126 Torino, Italy

Studio Oculistico A. Vercesi, Via Massa Saluzzo 20, 15057 Tortona, Italy

Funding

LINKS Foundation (Torino, Italy), LIFTT (Torino, Italy), Fondazione Compagnia di San Paolo (Torino, Italy) and Politecnico di Torino (Italy)

References (59)

Show source-provided references
1. Parsadaniantz, S.M., le Goazigo, A.R., Sapienza, A., Habas, C., and Baudouin, C. (2020). Glaucoma: A Degenerative Optic Neuropathy Related to Neuroinflammation?. Cells, 9.10.3390/cells9030535 ↗
2. The number of people with glaucoma worldwide in 2010 and 202010.1136/bjo.2005.081224 ↗
3. Intrinsically Photosensitive Retinal Ganglion Cells10.1152/physrev.00013.2010 ↗
4. Evaluation of pupillary response to light in patientswith glaucoma: A study using computerized pupillometry10.1007/s10792-014-9920-1 ↗
5. Response of Retinal Vessel Diameters to Flicker Stimulation in Patients with Early Open Angle Glaucoma10.1097/00061198-200408000-00013 ↗
6. Light at the end of the tunnel? Advances in the understanding and treatment of glaucoma and inherited retinal degeneration10.1016/j.tvjl.2006.08.014 ↗
7. Theoretical biophysical approach to cross-linking effects on eyes pressure10.1016/j.physa.2019.122163 ↗
8. Glaucoma as a neurodegenerative disease10.1097/ICU.0b013e3280895aea ↗
9. Optic Nerve Regeneration: Considerations on Treatment of Acute Optic Neuropathy and End-Stage Disease10.1007/s40135-019-00194-0 ↗
10. Effect of experimental glaucoma on the non-image forming visual system10.1111/j.1471-4159.2011.07260.x ↗
11. Vision Restoration in Glaucoma by Activating Residual Vision with a Holistic, Clinical Approach: A Review
12. Restoration of vision by training of residual functions10.1097/00055735-200012000-00008 ↗
13. Management of glaucoma as a neurodegenerative disease10.2217/nmt-2017-0004 ↗
14. Vision Restoration Through Extrastriate Stimulation in Patients With Visual Field Defects: A Double-Blind and Randomized Experimental Study10.1177/1545968308324221 ↗
15. Lucia, U., and Grisolia, G. (2020). Thermal Physics and Glaucoma: From Thermodynamic to Biophysical Considerations to Designing Future Therapies. Appl. Sci., 10.10.3390/app10207071 ↗
16. de Oliveira Rosso, M.P., Buchaim, D.V., Kawano, N., Furlanette, G., Pomini, K.T., and Buchaim, R.L. (2018). Photobiomodulation Therapy (PBMT) in Peripheral Nerve Regeneration: A Systematic Review. Bioengineering, 5.10.3390/bioengineering5020044 ↗
17. Chapter 13—Vision restoration after brain and retina damage: The “residual vision activation theory”
18. Strategies to Promote Long-Distance Optic Nerve Regeneration10.3389/fncel.2020.00119 ↗
19. Clinical Trial of a Novel Non-Thermal LED Array for Reversal of Photoaging: Clinical, Histologic, and Surface Profilometric Results10.1002/lsm.20107 ↗
20. Varying Ratios of Wavelengths in Dual Wavelength LED Photomodulation Alters Gene Expression Profiles in Human Skin Fibroblasts10.1002/lsm.20947 ↗
21. Neural activity promotes long-distance, target-specific regeneration of adult retinal axons10.1038/nn.4340 ↗
22. Glaucoma: Biological Trabecular and Neuroretinal Pathology with Perspectives of Therapy Innovation and Preventive Diagnosis10.3389/fnins.2017.00494 ↗
23. Zimmerman, J.F., and Tian, B. (2018). Nongenetic optical methods for measuring and modulating neuronal response. ACS Nano, 12.10.1021/acsnano.8b02758 ↗
24. Wang, M., Xu, Z., Liu, Q., Sun, W., Jiang, B., Yang, K., Li, J., Gong, Y., Liu, Q., and Liu, D. (2019). Nongenetic optical modulation of neural stem cell proliferation and neuronal/glial differentiation. Biomaterials, 225.10.1016/j.biomaterials.2019.119539 ↗
25. Osborne, N., Núnez-Álvarez, C., del Olmo-Aguado, S., and Merrayo-Lloves, J. (2017). Visual light effects on mitochondria: The potential implications in relation to glaucoma. Mitochondrion, 36.10.1016/j.mito.2016.11.009 ↗
26. Membrane potential and cancer progression10.3389/fphys.2013.00185 ↗
27. Atkins, P., and Paula, J.D. (2006). Physical Chemistry Life Science, Oxford University Press.
28. Lucia, U., and Grisolia, G. (2020). Thermal Resonance and Cell Behavior. Entropy, 22.10.3390/e22070774 ↗
29. Resonance in thermal fluxes through cancer membrane
30. Ashrafuzzaman, M., and Tuszynski, J. (2013). Membrane Biophysics, Springer.10.1007/978-3-642-16105-6 ↗
31. The mechanism of rotating proton pumping ATPases10.1016/j.bbabio.2010.02.014 ↗
32. Structure, function and regulation of the vacuolar (H+)-ATPase10.1146/annurev.cellbio.13.1.779 ↗
33. A thermo-physical analysis of the proton pump vacuolar-ATPase: The constructal approach10.1038/srep06763 ↗
34. How TCRs bind MHCs, peptides, and coreceptors10.1146/annurev.immunol.23.021704.115658 ↗
35. Asymmetric ligand recognition by the activating natural killer cell receptor NKG2D, a symmetric homodimer10.1016/S0161-5890(02)00032-9 ↗
36. The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy10.3892/ijmm.2017.3036 ↗
37. Constructal approach to bio-engineering: The ocular anterior chamber temperature10.1038/srep31099 ↗
38. Constructal law analysis of Cl− transport in eyes aqueous humor10.1038/s41598-017-07357-8 ↗
39. Callen, H.B. (1960). Thermodynamics, Wiley.
40. Yourgrau, W., van der Merwe, A., and Raw, G. (1982). Treatise on Irreversible and Statistical Thermophysics, Dover.
41. Lucia, U., and Grisolia, G. (2020). How Life Works—A Continuous Seebeck-Peltier Transition in Cell Membrane?. Entropy, 22.10.3390/e22090960 ↗
42. Lucia, U., and Grisolia, G. (2020). Non-equilibrium thermodynamic approach to Ca2+-fluxes in cancer. Appl. Sci., 10.10.3390/app10196737 ↗
43. Marois, M. (1969). Structure, Dissipation and Life. Theoretical Physics and Biology, North Holland Pub. Co.
44. Reaching the brain: Advances in optic nerve regeneration10.1016/j.expneurol.2015.12.015 ↗
45. Regenerating optic pathways from the eye to the brain10.1126/science.aal5060 ↗
46. Can mammalian vision be restored following optic nerve degeneration?10.2147/JN.S109523 ↗
47. Optical biopsy and imaging using optical coherence tomography10.1038/nm0995-970 ↗
48. The Use of Computed Tomography in Ophthalmology10.1148/115.2.361 ↗
49. Analysis of normal retinal nerve fiber layer thickness by age, sex, and race using spectral domain optical coherence tomography10.1097/IJG.0b013e318255bb4a ↗
50. Reproducibility of retinal nerve fiber thickness measurements using the stratus OCT in normal and glaucomatous eyes10.1167/iovs.04-1174 ↗
51. Reproducibility of peripapillary retinal nerve fiber thickness measurements with stratus OCT in glaucomatous eyes10.1016/j.ophtha.2007.05.035 ↗
52. Quantification of the retinal nerve fibre layer thickness in normal Indian eyes with optical coherence tomography
53. Histological measurement of retinal nerve fibre layer thickness10.1038/sj.eye.6701569 ↗
54. Fomins, S., and Ozolinsh, M. (2019). Mechanisms of color vision and dyschromatopsi. The 25th Symposium of the International Colour Vision Society, Latvia 5–9 July 2019: Book of the Abstract, University of Latvia.
55. Computer-based training for the treatment of partial blindness10.1038/2079 ↗
56. Residual Vision in Transition Zones in Patients with Cerebral Blindness10.1076/jcen.20.5.581.1129 ↗
57. Bergandi, L., Silvagno, F., Grisolia, G., Ponzetto, A., Rapetti, E., Astori, M., Vercesi, A., and Lucia, U. (2021). The Potential of Visible and Far-Red to Near-Infrared Light in Glaucoma Neuroprotection. Appl. Sci., 11.10.3390/app11135872 ↗
58. Niewiadomska-Kapla, J. (2018). Codici Percettivo del Colore e le Effettive Sensibilità dei Fotorecettori, Aracne.
59. Bejan, A. (2006). Advanced Engineering Thermodynamics, Wiley & Sons.