In Silico Analysis of the Antigenic Properties of Iron-Regulated Proteins against Neisseria meningitidis
Source abstract
Abstract
Neisseria meningitidis is a commensal pathogen that causes infectious cerebrospinal disease in people of all ages. The multivariate role of six disease-causing polysaccharide serotypes is found to play a crucial role in developing vaccines (or general treatment strategies) to treat this emerging pathogen. Iron is a crucial transition metal for N. meningitidis. Proteomic analysis data could be valuable for vaccine design. Here, we conduct a comparative study using computational bioinformatic tools to identify the most effective iron-regulated outer membrane proteins (OMPs) as immunogenic targets for a potential vaccine against N. meningitidis. The basic properties of N. meningitidis OMPs are explored for flexibility, solubility, hydrophilicity, beta-turns, and overall antigenic probability. Results of our study suggest that iron-regulated OMPs are flexible and soluble in water with high densities of conformational B-cell epitopes. As such, they can be recommended as a novel candidate for a vaccine against N. meningitidis both in vitro and in vivo.
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Research context
OpenAlex topics: Bacterial Infections and Vaccines · Peptidase Inhibition and Analysis · vaccines and immunoinformatics approaches
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Genetic Engineering and Biotechnology, Jashore University of Science and Technology, Jashore 7408, Bangladesh
Department of Stem Cell and Regenerative Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea
Faculty of Industrial Sciences & Technology, Universiti Malaysia Pahang, Kuantan 26300, Malaysia
Department of Chemical Engineering, Jashore University of Science and Technology, Jashore 7408, Bangladesh
Department of Bioscience, Arctic Research Centre (ARC), Aarhus University, Frederiksborgvej 399, P.O. Box 358, DK-4000 Roskilde, Denmark
Department of Civil and Environmental Engineering, Hanyang University, 222 Wangsimni-Ro, Seoul 04763, Korea
Funding
National Research Foundation of Korea
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