Picrasma quassioides (D.DON) Benn. Ethanolic Extract Improves Atopic Dermatitis and Hyperactivity Disorder in DNCB-Treated BALB/c Mice
Source abstract
Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disorder that can be associated with psychiatric disorders. Picrasma quassioides (D.Don) Benn (Gomokpi, GMP), a traditional medicinal herb, has been used to treat skin diseases, including AD. The current study examined the effects of an ethanolic extract of GMP on 2,4-dinitrochlorobenzene (DNCB)-induced AD mice. The severity of skin symptoms and behavioral changes in AD mice were evaluated. GMP alleviated the AD-like skin inflammation and hyperlocomotion activity in DNCB-treated BALB/c mice. The effects of GMP behavioral abnormalities might occur by inhibiting TNF-α production in the PFC. GMP suppressed the production of TARC (Th2 chemokine) in TI-stimulated HaCaT keratinocytes. Moreover, GMP also exerted immunosuppressive effects by reducing TNF-α production in LPS-stimulated Raw264.7 macrophages, IL-17 expression in PI-stimulated EL4 cells, and VEGF secretion in SP-stimulated HMC-1 cells. These findings suggest that GMP could be useful for treating AD by modulating inflammatory responses and comorbid behavioral changes.
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Research context
OpenAlex topics: Dermatology and Skin Diseases · Phytochemical compounds biological activities · Transgenic Plants and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Physiology, College of Korean Medicine Dongguk University, Gyeongju 38066, Korea
Funding
Ministry of Education
References (49)
Show source-provided references
1. Comparison of Clinical Severity and Laboratory Results between Atopic and Non-atopic Eczema in Children
2. Anti-Atopic Effect of DNCB-Induced Mouse in Chondrus canaliculatus Ethanol Extracts
3. Effects of Rumecis Radix Water Extract on Development of Atopic Dermatitis in BALB/c Mice
4. Huang-Lian-Jie-Du extract ameliorates atopic dermatitis-like skin lesions induced by 2,4-dinitrobenzene in mice via suppression of MAPKs and NF-κB pathways10.1016/j.jep.2019.112367 ↗
5. Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 110.1073/pnas.88.10.4220 ↗
6. Role of Mast Cells in Allergic Inflammation and Innate Immunity
7. Keratinocytes: Innate immune cells in atopic dermatitis10.1111/cei.13575 ↗
8. Cytokines and the skin barrier10.3390/ijms14046720 ↗
9. Mental health comorbidity in patients with atopic dermatitis10.1016/j.jaci.2012.10.041 ↗
10. Association between atopic dermatitis and attention deficit hyperactivity disorder in U.S. children and adults10.1111/bjd.14697 ↗
11. Attention deficit hyperactivity disorder may be a highly inflammation and immune-associated disease (Review)10.3892/mmr.2017.7228 ↗
12. A Review on the Role of Inflammation in Attention-Deficit/Hyperactivity Disorder10.1159/000489635 ↗
13. Avoidance behavior and neural correlates of allergen exposure in a murine model of asthma10.1016/j.bbi.2004.02.005 ↗
14. Longitudinal mapping of cortical thickness and clinical outcome in children and adolescents with attention-deficit/hyperactivity disorder10.1001/archpsyc.63.5.540 ↗
15. Altered hypothalamus-pituitary-adrenal axis function: A relevant factor in the comorbidity of atopic eczema and attention deficit/hyperactivity disorder?10.1016/j.psyneuen.2018.12.005 ↗
16. Anti-Inflammatory Effects of Picrasma Quassioides (D.DON) BENN Leaves Extracts
17. Studies for Component Analysis and Biological Evaluation in Picrasma quassioides (D.Don) Benn. Extract
18. Pharmacological effects of Picrasma quassioides (D. Don) Benn for inflammation, cancer and neuroprotection (Review)10.3892/etm.2021.10792 ↗
19. Inhibitory effects of Picrasma quassioides (D.Don) Benn. on airway inflammation in a murine model of allergic asthma10.3892/mmr.2014.2322 ↗
20. The inhibitory effect of Picrasmae Lignum on inflammatory responses
21. Kanda, N., Hoashi, T., and Saeki, H. (2019). The Roles of Sex Hormones in the Course of Atopic Dermatitis. Int. J. Mol. Sci., 20.10.3390/ijms20194660 ↗
22. Atopic dermatitis in the pediatric population: A cross-sectional, international epidemiologic study10.1016/j.anai.2020.12.020 ↗
23. Epidemiology of atopic dermatitis in adults: Results from an international survey10.1111/all.13401 ↗
24. Major Comorbidities of Atopic Dermatitis: Beyond Allergic Disorders10.1007/s40257-018-0383-4 ↗
25. Childhood atopic dermatitis as a precursor for developing attention deficit/hyperactivity disorder10.1177/2058738420962902 ↗
26. Prevalence of attention-deficit/hyperactivity disorder: A systematic review and meta-analysis10.1542/peds.2014-3482 ↗
27. Molecular Mechanism of Atopic Dermatitis Induction Following Sensitization and Challenge with 2,4-Dinitrochlorobenzene in Mouse Skin Tissue10.5487/TR.2018.34.1.007 ↗
28. Multipolarity of cytokine axes in the pathogenesis of atopic dermatitis in terms of age, race, species, disease stage and biomarkers10.1093/intimm/dxy015 ↗
29. Mast cells in atopic dermatitis10.1016/j.coi.2009.09.006 ↗
30. The role of mast cells in allergic inflammation10.1016/j.rmed.2011.09.007 ↗
31. Mast Cell: A Multi-Functional Master Cell
32. Role of Macrophages in the Pathogenesis of Atopic Dermatitis10.1155/2013/942375 ↗
33. Regulation of T Cell Immunity in Atopic Dermatitis by Microbes: The Yin and Yang of Cutaneous Inflammation10.3389/fimmu.2015.00353 ↗
34. Atopic dermatitis10.1016/S0140-6736(03)12193-9 ↗
35. Crosstalk between keratinocytes and T cells in a 3D microenvironment: A model to study inflammatory skin diseases10.1038/jid.2013.417 ↗
36. Serum levels of Th2 chemokines, CCL17, CCL22, and CCL27, were the important markers of severity in infantile atopic dermatitis10.1111/j.1399-3038.2007.00692.x ↗
37. New insights into T cells and their signature cytokines in atopic dermatitis10.1002/iub.1405 ↗
38. T helper (Th)1, Th17 and Th2 imbalance in mesenchymal stem cells of adult patients with atopic dermatitis: At the origin of the problem10.1111/bjd.15078 ↗
39. IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models10.1038/jid.2014.51 ↗
40. Interleukin-17A promotes IgE production in human B cells10.1038/jid.2010.175 ↗
41. Association of attention-deficit/hyperactivity disorder and atopic eczema modified by sleep disturbance in a large population-based sample10.1136/jech.2009.093534 ↗
42. Psychoendocrine and psychoneuroimmunological mechanisms in the comorbidity of atopic eczema and attention deficit/hyperactivity disorder10.1016/j.psyneuen.2012.09.017 ↗
43. Neuroinflammation as a risk factor for attention deficit hyperactivity disorder10.1016/j.pbb.2019.05.005 ↗
44. Mast cell-mediated neuroinflammation may have a role in attention deficit hyperactivity disorder (Review)10.3892/etm.2020.8789 ↗
45. Corona, J.C. (2020). Role of Oxidative Stress and Neuroinflammation in Attention-Deficit/Hyperactivity Disorder. Antioxidants, 9.10.3390/antiox9111039 ↗
46. Hong, J.E., Park, M.-c., Kang, S.-J., Yang, G.-J., and Jo, E.H. (2020). New Interpretation on MyeonGu of Baekho-Tang Text of Shanghanlun through Case Reports, The Physiological Society of Korean Medicine and the Society of Pathology in Korean Medicine.10.15188/kjopp.2020.02.34.1.45 ↗
47. Effects of Three Types of GagamBangpungtongseong-san(Except Talcum) on the Atopic Dermatitis in Mice
48. Quassin alters the immunological patterns of murine macrophages through generation of nitric oxide to exert antileishmanial activity10.1093/jac/dkn479 ↗
49. Quassinoids with Insecticidal Activity against Diaphorina citri Kuwayama and Neuroprotective Activities from Picrasma quassioides10.1021/acs.jafc.9b05796 ↗