Anti-Aging Effects of Polyoxometalates on Skin
Source abstract
Abstract
Excessive reactive oxygen species (ROS) generation by inflammation and glycation contributes to various aging-related changes in the body. Therefore, inhibiting ROS production can prevent wrinkles, maculae, dullness, and slackness in skin. To assess the anti-aging effects of two polyoxometalates (PMs: VB2 and VB3) on skin, this study investigated whether they ameliorated the anti-aging responses of normal human dermal fibroblasts (NHDF) to oxidative stress due to ad-vanced glycation end products (AGEs) or H2O2 exposure. Compared with the mRNA expression levels of AGE receptors in cells exposed to AGEs alone, an additional treatment with VB2 or VB3 significantly increased the expression levels of FEEL-1, FEEL-2, and RAGE. Under AGE-induced stress conditions, the expression levels of five heat shock proteins were markedly increased by the VB treatments. Conversely, VBs suppressed the induction of cell death and intracellular ROS production. VBs also exerted prophylactic effects on these harmful events under stress conditions. Furthermore, VB treatments were found to prevent both the suppression of AQP-1/AQP-3 expression and the suppression of hyaluronan and elastin production induced via H2O2 exposure. These results show the potential of VB2 and VB3 as anti-aging agents.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Skin Protection and Aging · Advanced Glycation End Products research · Dyeing and Modifying Textile Fibers
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
FSX, Inc., 1-12-3, Izumi, Kunitachi, Tokyo 186-0012, Japan
Department of Health Medicine, Yokohama University of Pharmacy, 601, Matano-cho, Totsuka-ku, Yokohama 245-0066, Japan
Division of Research and Development, Research Organization of Biological Activity, Crest #301, 3-44-13, Minami-ohtsuka, Toshima-ku, Tokyo 170-0005, Japan
References (41)
Show source-provided references
1. Phagocytes and oxidative stress10.1016/S0002-9343(00)00481-2 ↗
2. A The signals and pathways activating cellular senescence10.1016/j.biocel.2004.10.013 ↗
3. A continuous correlation between oxidative stress and telomere shortening in fibroblasts10.1016/j.exger.2007.08.005 ↗
4. Mechanism of apoptosis induced by a new topoisomerase inhibitor through the generation of hydrogen peroxide10.1074/jbc.M204353200 ↗
5. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase10.1126/science.1094637 ↗
6. Glycative Stress and Anti-Aging: 7. Glycative stress and skin aging
7. Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence10.1038/s41467-019-12398-w ↗
8. Nonenzymatic glycation of collagen in aging and diabetes10.3181/00379727-218-44264 ↗
9. Involvement of Maillard reactions in Alzheimer disease10.1080/1029840290007321 ↗
10. Advanced glycation end products are associated with pulse pressure in type 1 diabetes: The EURODIAB Prospective Complications Study10.1161/01.HYP.0000164574.60279.ba ↗
11. Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking10.1126/science.3487117 ↗
12. Reductions in degree of mineralization and enzymatic collagen cross-links and increases in glycation-induced pentosidine in the femoral neck cortex in cases of femoral neck fracture10.1007/s00198-006-0087-0 ↗
13. Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and aging10.1016/S1383-5742(00)00059-4 ↗
14. Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling10.1083/jcb.201708007 ↗
15. Aquaporin-3 Attenuates oxidative stress-induced nucleus pulposus cell apoptosis through regulating the P38 MAPK pathway10.1159/000494788 ↗
16. Matrix-degrading metalloproteinases in photoaging10.1038/jidsymp.2009.8 ↗
17. Xu, Q., Hou, W., Zheng, Y., Liu, C., Gong, Z., Lu, C., Lai, W., and Maibach, H.I. (2014). Ultraviolet A-induced cathepsin K expression is mediated via MAPK/AP-1 pathway in human dermal fibroblasts. PLoS ONE, 9.10.1371/journal.pone.0102732 ↗
18. Polyoxometalates active against tumors, viruses, and bacteria Review10.1007/978-3-642-41004-8_4 ↗
19. Mechanism of the protective effect of heteropolyoxotungstate against herpes simplex virus type 210.1159/000067738 ↗
20. Dan, K., Fujinami, K., Sumitomo, H., Ogiwara, Y., Suhara, S., Konno, Y., Sawada, M., Soga, Y., Takada, A., and Takanashi, K. (2020). Application of antiviral polyoxometalates to living environments-Antiviral moist hand towels and stationery items. Appl. Sci., 10.10.3390/app10228246 ↗
21. Sulforaphane inhibits advanced glycation end product-induced pericyte damage by reducing expression of receptor for advanced glycation end products10.1016/j.nutres.2014.08.010 ↗
22. Oxidative stress upregulates the transcription of genes involved in thiamine metabolism10.3906/biy-1801-51 ↗
23. AGE/RAGE-induced EMP release via the NOX-derived ROS pathway10.1155/2018/6823058 ↗
24. Stoll, S.J., Bartsch, S., and Kroll, J. (2013). HOXC9 regulates formation of parachordal lymphangioplasts and the thoracic duct in zebrafish via stabilin 2. PLoS ONE, 8.10.1371/journal.pone.0058311 ↗
25. TGF-beta1 downregulates CD36 and scavenger receptor A but upregulates LOX-1 in human macrophages10.1152/ajpheart.2000.278.4.H1042 ↗
26. The expression of advanced glycation endproduct receptors in rpe cells associated with basal deposits in human maculas10.1016/j.exer.2005.10.005 ↗
27. Age-dependent expression of advanced glycation end product receptor genes in the human heart10.1159/000076770 ↗
28. Expression, Localization and potential significance of aquaporins in benign and malignant human prostate tissue10.1186/s12894-018-0391-y ↗
29. FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products10.1074/jbc.M210211200 ↗
30. RAGE and soluble RAGE: Potential therapeutic targets for cardiovascular diseases10.2119/2007-00087.Koyama ↗
31. Lee, A.C., Lam, J.K., Shiu, S.W., Wong, Y., Betteridge, D.J., and Tan, K.C. (2015). Serum level of soluble receptor for advanced glycation end products is associated with a disintegrin and metalloproteinase 10 in type 1 diabetes. PLoS ONE, 10.10.1371/journal.pone.0137330 ↗
32. Split conformation of Chaetomium thermophilum Hsp104 disaggregase10.1016/j.str.2021.02.002 ↗
33. Cellular Requirements for tumor-specific immunity elicited by heat shock proteins: Tumor rejection antigen gp96 primes CD8+T cells in vivo10.1073/pnas.91.8.3077 ↗
34. Molecular chaperone Hsp90 regulates REV1-mediated mutagenesis10.1128/MCB.05117-11 ↗
35. A motif in the clathrin heavy chain required for the Hsc70/auxilin uncoating reaction10.1091/mbc.e07-09-0870 ↗
36. Chaperone-mediated autophagy: Dice’s ‘wild’ idea about lysosomal selectivity10.1038/nrm3150 ↗
37. Chaperonin-mediated protein folding10.1074/jbc.X113.497321 ↗
38. Protective Effect of Boswellic Acids Against Doxorubicin-induced hepatotoxicity: Impact on Nrf2/HO-1 defense pathway10.1155/2018/8296451 ↗
39. Prospective, randomized, investigator-blinded, split-face evaluation of a topical crosslinked hyaluronic acid serum for post-procedural improvement of skin quality and biomechanical attributes
40. Use of ivermectin in treatment of Aelurostrongylus abstrusus and Toxocara cati infection in a cat
41. Effects of 7-MEGATM 500 on oxidative stress, inflammation, and skin regeneration in H2O2-treated skin cells10.5487/TR.2018.34.2.103 ↗