Does the Intraluminal Thrombus Provoke the Rupture of the Abdominal Aortic Aneurysm Wall?
Source abstract
Abstract
The role of intraluminal thrombus (ILT) in the rupture of abdominal aortic aneurysms (AAA) is controversial, and it is unclear whether it increases or decreases the risk of rupture. This research aims to find a clear answer to this question. Previous computer modelling suggests that an ILT lowers oxygen dissemination to the AAA wall, contributing to wall thinning. The methodology used in this study determines the amount of oxygen reaching the aneurysm wall after passing through the ILT by using the porous nature of the ILT to recreate the condition as closely as feasible. Using computed tomographic images, patient-specific three-dimensional (3D) AAA geometries were recreated. Modelling blood and oxygen flow in AAA was obtained using a computational fluid dynamics (CFD) approach. Our findings indicated that the oxygen volume percentage had completely reached the aneurysm wall. Only at the inlet and outflow did the greatest wall shear stress (WSS) occur, with a significant drop in the central region of the aneurysm wall. CFD was used to calculate the velocity, pressure, and WSS of aortic blood flow. ILT had no effect on oxygen flow to the aneurysm wall, disproving the theory that it produces local hypoxia.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Aortic aneurysm repair treatments · Vascular Procedures and Complications · Cardiac, Anesthesia and Surgical Outcomes
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Biomedical Technology Department, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia
Funding
Deanship of Scientific Research at King Saud University
References (46)
Show source-provided references
1. Non-Newtonian and Newtonian blood flow in human aorta: A transient Analysis
2. White, H.J., Bordes, S., and Borger, J. (2021). Anatomy, Abdomen and Pelvis, Aorta, StatPearls Publishing.
3. Physiological pulsatile flow experiments in a model of the human aortic arch10.1016/0021-9290(82)90023-9 ↗
4. A Numerical Study of Aortic Flow Stability and Comparison With In Vivo Flow Measurements10.1115/1.4023132 ↗
5. Entry flow in a curved pipe10.1017/S0022112075000237 ↗
6. Fluid motion in a curved pipe10.1098/rspa.1928.0205 ↗
7. Calculation of Unsteady Flows in Curved Pipes10.1115/1.1400748 ↗
8. An experimental study of pulsatile flow in a curved tube10.1016/0021-9290(79)90165-9 ↗
9. Experimental study of physiological pulsatile flow in a curved tube10.1017/S0022112081002292 ↗
10. Computational fluid dynamics modelling in cardiovascular medicine10.1136/heartjnl-2015-308044 ↗
11. Impact of calcification and intraluminal thrombus on the computed wall stresses of abdominal aortic aneurysm10.1016/j.jvs.2008.01.006 ↗
12. Design of the abdominal aortic Aneurysm Detection and Management Study10.1016/0741-5214(94)90019-1 ↗
13. Selective management of abdominal aortic aneurysms in a prospective measurement program10.1016/S0741-5214(96)70265-3 ↗
14. Effect of intraluminal thrombus on wall stress in patient-specific models of abdominal aortic aneurysm10.1067/mva.2002.126087 ↗
15. Biomechanical Determinants of Abdominal Aortic Aneurysm Rupture10.1161/01.ATV.0000174129.77391.55 ↗
16. Association of intraluminal thrombus in abdominal aortic aneurysm with local hypoxia and wall weakening10.1067/mva.2001.114813 ↗
17. Ultrasonic evaluation of abdominal aortic thrombus10.7863/jum.1982.1.8.315 ↗
18. Computed tomography scanning findings associated with rapid expansion of abdominal aortic aneurysms10.1016/0741-5214(94)90277-1 ↗
19. Biomechanical factors in abdominal aortic aneurysm rupture10.1016/S0950-821X(05)80714-5 ↗
20. Effect of intraluminal thrombus on abdominal aortic aneurysm wall stress10.1016/S0741-5214(97)70058-2 ↗
21. Biomechanics of abdominal aortic aneurysm in the presence of endoluminal thrombus: Experimental characterisation and structural static computational analysis10.1016/S1078-5884(98)80031-2 ↗
22. Pathophysiology and Pathogenesis of Aortic Aneurysms: Current Concepts10.1016/S0039-6109(16)44876-0 ↗
23. Thrombus within an aortic aneurysm does not reduce pressure on the aneurysmal wall10.1067/mva.2000.103693 ↗
24. Intraluminal thrombus predicts rupture of an abdominal aortic aneurysm10.1016/S0741-5214(96)80062-0 ↗
25. Dynamic quantification, visualisation and animation of blood velocities and flows in infrarenal aortic aneurysms in vivo by three-dimensional MR phase velocity encoding10.1016/S1078-5884(05)80004-8 ↗
26. Morphology of small aneurysms: Definition and impact on risk of rupture10.1016/S0002-9610(94)80052-9 ↗
27. Effect of shape of intraluminal thrombus on wall stress in abdominal aortic aneurysm. Biomedical Engineering Society
28. Cellular content and permeability of intraluminal thrombus in abdominal aortic aneurysm10.1016/S0741-5214(97)70223-4 ↗
29. Impact of poroelasticity of intraluminal thrombus on wall stress of abdominal aortic aneurysms10.1186/1475-925X-11-62 ↗
30. Relating oxygen partial pressure, saturation and content: The haemoglobin–oxygen dissociation curve10.1183/20734735.001415 ↗
31. Dwidmuthe, P., Mathpati, C., and Joshi, J. (2018, January 10–12). CFD Simulation of Blood Flow Inside the Human Artery: Aorta. Proceedings of the 7th International and 45th National Conference on Fluid Mechanics and Fluid Power (FMFP), Mumbai, India.
32. On the paths of fluid particles in an axisymmetrical aneurysm10.1016/0021-9290(87)90297-1 ↗
33. The Effect of Asymmetry in Abdominal Aortic Aneurysms Under Physiologically Realistic Pulsatile Flow Conditions10.1115/1.1543991 ↗
34. Biomechanical rupture risk assessment of abdominal aortic aneurysms: Model complexity versus predictability of finite element simulations10.1016/j.ejvs.2010.04.003 ↗
35. The relationship between wall shear stress distributions and intimal thickening in the human abdominal aorta10.1186/1475-925X-2-18 ↗
36. Analysis and computer program for rupture-risk prediction of abdominal aortic aneurysms10.1186/1475-925X-5-19 ↗
37. The effect of oxygen on the development of atherosclerosis in WHHL rabbits10.1016/0021-9150(83)90070-9 ↗
38. Some Observations on the Pathogenesis and Natural History of Intracranial Aneurysms10.1136/jnnp.22.4.259 ↗
39. Mechanism of Growth and Rupture in Cerebral Berry Aneurysms10.1136/bmj.1.5496.1138 ↗
40. Hemodynamics for Surgeons10.1001/archsurg.1976.01360260097031 ↗
41. Low wall shear stress predominates at sites of abdominal aortic aneurysm rupture10.1016/j.jvs.2015.01.040 ↗
42. Intraluminal Thrombus Predicts Rapid Growth of Abdominal Aortic Aneurysms
43. Intraluminal thrombus: Innocent bystander or factor in abdominal aortic aneurysm pathogenesis?10.1016/j.jvssci.2021.02.001 ↗
44. Factor Xa inhibitor rivaroxaban suppresses experimental abdominal aortic aneurysm progression via attenuating aortic inflammation10.1016/j.vph.2020.106818 ↗
45. Influence of intraluminal thrombus on structural and cellular composition of abdominal aortic aneurysm wall10.1016/S0741-5214(03)00791-2 ↗
46. Effect of Intraluminal Thrombus Thickness and Bulge Diameter on the Oxygen Diffusion in Abdominal Aortic Aneurysm10.1115/1.2834747 ↗