Novel Epigallocatechin-3-Gallate (EGCG)-Loaded Mesoporous Bioglass Scaffolds for Bone Recruitment Applications
Source abstract
Abstract
Bioglass-based material has been widely used in the field of biomedical science. In this study, the proper concentration of epigallocatechin-3-gallate (EGCG) for a mesoporous bioglass (MBG) scaffold was determined based on the sponge replication method. The fabrication procedure performed using a foam exchange technique resulted in an interconnected network of pores scaffolds with no cracks. In the minimum bactericidal concentrations of the bacteria assessed, the antibacterial concentration of EGCG against E. coli (200 μg/mL) was higher than that against S. aureus (25 μg/mL). The MBG and EGCG-MBG scaffolds exhibited excellent apatite mineralization and drug release abilities (the highest cumulative drug release from the EGCG-MBG scaffold was 75.37%). Thus, a 200 μg/mL EGCG can prevent cell apoptosis and directly enhance cell proliferation. Hence, a low-dose EGCG-MBG scaffold is another option for bone recruitment material.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Dental Implant Techniques and Outcomes · Dental materials and restorations
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Mold and Die Engineering, National Kaohsiung University of Science and Technology, Kaohsiung 807, Taiwan
Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan
School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
UniSA Clinical & Health Sciences, University of South Australia, Adelaide, SA 5001, Australia
Funding
Ministry of Science and Technology
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