An Innovative Bioceramic Bone Graft Substitute for Bone Defect Treatment: In Vivo Evaluation of Bone Healing
Source abstract
Abstract
This study aimed to analyze characteristics of an innovative α-calcium sulfate hemihydrate (α-CSH) bioceramic and bone healing and regeneration characteristics following its implantation on artificially created defects of rat models and human jaw defects. The α-CSH bioceramic was characterized using field emission scanning electron microscope (FE-SEM), energy-dispersive spectroscopy (EDS), and thermal-imaging instruments. The material was implanted on artificially created defects in a rat’s right hind leg bone and observed histologically after three days and seven weeks. The material was also implanted in patients with bone defects in the posterior maxillary, then observed immediately and six months post-treatment by panoramic and computed tomography image. The FE-SEM confirm this material is a uniform-shaped short column crystal, while the EDS measurement reveals calcium as the most component in this material. Thermal observation shows temperature change during the setting time is less than 2 °C, and the maximum temperature reached is 31 °C. In the histological analysis, α-CSH bioceramic shows new trabecular bone formation and absorbed material at seven weeks post-treatment. Moreover, panoramic and computed tomography image shows intact bone six months post-treatment. Therefore, this study suggests that the innovative α-CSH bioceramic can be useful in bone defect treatment.
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Research context
OpenAlex topics: Bone Tissue Engineering Materials · Dental Implant Techniques and Outcomes · Titanium Alloys Microstructure and Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Graduate Institute of Dental Science, College of Dentistry, China Medical University, Taichung 404, Taiwan
Biomedical Technology R & D Center, China Medical University Hospital, Taichung 404, Taiwan
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan
School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
Department of Oral Hygiene Care, Ching Kuo Institute of Management and Health, Keelung 203, Taiwan
Asia Pacific Laser Institute, New Taipei City 220, Taiwan
Implant Academy of Minimally Invasive Dentistry, Taipei 106, Taiwan
Department of Dentistry and Oral Surgery, Osaka Medical College, Osaka 569-8686, Japan
Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido 061-0293, Japan
Division of Prosthodontics, Department of Dentistry, Taipei Medical University Hospital, Taipei 110, Taiwan
3D Global Biotech Inc. (Spin-off Company from Taipei Medical University), New Taipei City 221, Taiwan
Funding
Ministry of Science and Technology, Taiwan
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