Detection of Choroidal Neovascularization by Optical Coherence Tomography Angiography with Assistance from Use of the Image Segmentation Method
Source abstract
Abstract
Optical coherence tomography angiography (OCTA) is a popular medical imaging technology that can quickly establish a three-dimensional model of the fundus without dye injection. However the number of images in a model is quite large, so finding the lesions through image processing technology can greatly reduce the time required for the judgment of the condition. This paper proposes a method for finding choroidal neovascularization (CNV) in OCTA images. Among the several characteristics of CNV, the larger turning angle of blood vessels is a relatively clear feature, so we will use this property to find out whether there is CNV in an OCTA image. We will transform the color space to CIELAB space, and extract the L-channel prior to preceding to the next step. We will then use some image segmentation methods to find the clearer vessel region. Finally, we will detect the CNV through certain morphology methods. The experimental result shows that our proposed method can effectively find the CNV in the OCTA image, meaning that we can make automated judgments through this method in the future and reduce the time necessary for human judgment.
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Research context
OpenAlex topics: Retinal Imaging and Analysis · Retinal Diseases and Treatments · Glaucoma and retinal disorders
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Ophthalmology, Taichung Veterans General Hospital, Taichung 40705, Taiwan
Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan
Department of Computer Science and Engineering, National Chung-Hsing University, Taichung 402, Taiwan
Department of Optometry, Central Taiwan University of Science and Technology, Taichung 40601, Taiwan
References (26)
Show source-provided references
1. Age-Related Macular Degeneration Is the Leading Cause of Blindness10.1001/jama.291.15.1900 ↗
2. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: A systematic review and meta-analysis10.1016/S2214-109X(13)70145-1 ↗
3. Quantitative Optical Coherence Tomography Angiography of Choroidal Neovascularization in Age-Related Macular Degeneration10.1016/j.ophtha.2014.01.034 ↗
4. The Neovascular Age-Related Macular Degeneration Database: Report 2: Incidence, Management, and Visual Outcomes of Second Treated Eyes10.1016/j.ophtha.2014.04.026 ↗
5. Reduced Fluorescein Angiography and Fundus Photography Use in the Management of Neovascular Macular Degeneration and Macular Edema During the Past Decade10.1167/iovs.13-13034 ↗
6. Fluorescein Angiography Complication Survey10.1016/S0161-6420(86)33697-2 ↗
7. Optical Radiomic Signatures Derived from Optical Coherence Tomography Images Improve Identification of Melanoma10.1158/0008-5472.CAN-18-2791 ↗
8. Swept-source optical coherence tomographic findings in eyes with metastatic choroidal tumor10.1016/j.ajoc.2017.10.005 ↗
9. Optical coherence tomography for the diagnosis of neovascular age-related macular degeneration: A systematic review10.1038/eye.2014.214 ↗
10. OCT angiography and evaluation of the choroid and choroidal vascular disorders10.1016/j.preteyeres.2018.07.002 ↗
11. Optical Coherence Tomography Angiography of Asymptomatic Neovascularization in Intermediate Age-Related Macular Degeneration10.1016/j.ophtha.2016.01.044 ↗
12. State-of-the-art in retinal optical coherence tomography image analysis
13. Gonzalez, R.C., and Woods, R.E. (2006). Digital Image Processing, Prentice-Hall, Inc.. [3rd].
14. A color calibration method between different digital cameras10.1016/j.ijleo.2015.12.003 ↗
15. Anaglyph image generation by matching color appearance attributes10.1016/j.image.2013.03.004 ↗
16. Margulis, D. (2006). Photoshop LAB Color: The Canyon Conundrum and Other Adventures in the Most Powerful Colorspace, Peachpit Press.
17. A Threshold Selection Method from Gray—Scale Histograms10.1109/TSMC.1979.4310076 ↗
18. ARCOCT: Automatic detection of lumen border in intravascular OCT images10.1016/j.cmpb.2017.08.007 ↗
19. Kong, T.Y., and Rosenfeld, A. (1996). Topological Algorithms for Digital Image Processing, Elsevier.
20. Thinning methodologies-a comprehensive survey10.1109/34.161346 ↗
21. Waheed, Z., Akram, M.U., Waheed, A., and Shaukat, A. (2015, January 15–17). Robust extraction of blood vessels for retinal recognition. Proceedings of the 2015 Second International Conference on Information Security and Cyber Forensics (InfoSec), Cape Town, South Africa.10.1109/InfoSec.2015.7435497 ↗
22. Natural History of Subclinical Neovascularization in Nonexudative Age-Related Macular Degeneration Using Swept-Source OCT Angiography10.1016/j.ophtha.2017.08.030 ↗
23. Two-Year Risk of Exudation in Eyes with Nonexudative Age-Related Macular Degeneration and Subclinical Neovascularization Detected with Swept Source Optical Coherence Tomography Angiography10.1016/j.ajo.2019.06.017 ↗
24. The Diagnostic Accuracy of Optical Coherence Tomography Angiography for Neovascular Age-Related Macular Degeneration: A Comparison with Fundus Fluorescein Angiography10.1155/2016/7521478 ↗
25. Sensitivity and Specificity of OCT Angiography to Detect Choroidal Neovascularization10.1016/j.oret.2017.02.007 ↗
26. BahadarKhan, K., Khaliq, A.A., and Shahid, M. (2016). A Morphological Hessian Based Approach for Retinal Blood Vessels Segmentation and Denoising Using Region Based Otsu Thresholding. PLoS ONE, 11.10.1371/journal.pone.0158996 ↗